Computational-guided determination of the functional role of 447-52D long CDRH3

Volume: 31, Issue: 12, Pages: 479 - 487
Published: Dec 1, 2018
Abstract
447-52D (447) is a human monoclonal antibody that recognizes a conserved epitope in the crown region of the third variable loop (V3) of HIV-1 gp120, and like many anti-HIV-1 antibodies with broad neutralization capabilities, it has a long heavy-chain complementarity determining region (CDRH3). Here, we use a combination of computational mutagenesis and modeling in tandem with fluorescence polarization assays to interrogate the molecular basis of...
Paper Details
Title
Computational-guided determination of the functional role of 447-52D long CDRH3
Published Date
Dec 1, 2018
Volume
31
Issue
12
Pages
479 - 487
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