Furanoeremophilanes from Euryops arabicus alleviate metabolic syndrome-associated exaggerated vasoconstriction via direct vasodilatation

• Euryops arabicus alleviated MetS associated exaggerated vasoconstriction. • The chloroform fraction yielded eight furanoeremophilane derivatives. • All isolated compounds showed significant vasodilation activity. • Vasodilation activity may involve calcium channel blocking mechanism. Abstract Exaggerated vasoconstriction plays a critical role in the development of hypertension in metabolic syndrome (MetS). A crude methanolic extract of Euryops...