Analysis of human cGAS activity and structure

Pages: 13 - 40
Published: Jan 1, 2019
Abstract
Cyclic GMP-AMP synthase (cGAS) is an innate immune system enzyme responsible for recognition of double-stranded DNA aberrantly localized in the cell cytosol. cGAS binds DNA and is activated to catalyze production of the nucleotide second messenger 2'-5'/3'-5' cyclic GMP-AMP (2'3' cGAMP). In spite of a major role for cGAS in the cellular immune response, a complete understanding of cGAS biology has been limited by a lack of genetic tools to...
Paper Details
Title
Analysis of human cGAS activity and structure
Published Date
Jan 1, 2019
Pages
13 - 40
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