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GlycA, a Novel Inflammatory Marker and Its Association With Peripheral Arterial Disease and Carotid Plaque: The Multi-Ethnic Study of Atherosclerosis.

Published on Sep 1, 2019in Angiology2.376
路 DOI :10.1177/0003319719845185
Oluwaseun E. Fashanu3
Estimated H-index: 3
(Johns Hopkins University),
Abayomi O. Oyenuga1
Estimated H-index: 1
(UMN: University of Minnesota)
+ 5 AuthorsErin Donnelly Michos41
Estimated H-index: 41
(Johns Hopkins University)
Abstract
GlycA, a composite biomarker of systemic inflammation, is associated with cardiovascular disease (CVD) and mortality, but its relationship with peripheral artery disease (PAD) is unknown. We assess...
  • References (42)
  • Citations (1)
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#1Angelica K. Ezeigwe (Johns Hopkins University)H-Index: 1
#2Oluwaseun E. Fashanu (Johns Hopkins University)H-Index: 3
Last. Erin Donnelly Michos (Johns Hopkins University)H-Index: 41
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Abstract Background and aims GlycA is a novel composite biomarker of systemic inflammation reflecting posttranslational glycosylation of acute phase reactants. GlycA has been associated with coronary artery calcium, cardiovascular disease (CVD) events and mortality. Vascular calcifications outside of the coronary arteries are risk markers of CVD and mortality. Whether GlycA is linked to extra-coronary calcifications (ECC) is not well established. Methods We studied 6462 MESA participants free of...
2 CitationsSource
#1Martin Tibuakuu (Johns Hopkins University)H-Index: 4
#2Oluwaseun E. Fashanu (Johns Hopkins University)H-Index: 3
Last. Erin Donnelly Michos (Johns Hopkins University)H-Index: 41
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3 CitationsSource
#1Eve Marie A. Benson (Johns Hopkins University)H-Index: 1
#2Martin Tibuakuu (Johns Hopkins University)H-Index: 4
Last. Erin Donnelly Michos (Johns Hopkins University)H-Index: 41
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#1Emelia J. BenjaminH-Index: 154
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Each chapter listed in the Table of Contents (see next page) is a hyperlink to that chapter. The reader clicks the chapter name to access that chapter. Each chapter listed here is a hyperlink. Click on the chapter name to be taken to that chapter. Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together in a single document the most up-to-date statistics r...
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Inflammatory pathways drive atherogenesis and link conventional risk factors to atherosclerosis and its complications. One inflammatory mediator has come to the fore as a therapeutic target in cardiovascular disease. The experimental and clinical evidence reviewed here support interleukin-1 beta (IL-1尾) as both a local vascular and systemic contributor in this regard. Intrinsic vascular wall cells and lesional leukocytes alike can produce this cytokine. Local stimuli in the plaque favor the gene...
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Abstract Inflammatory pathways drive atherogenesis and link conventional risk factors to atherosclerosis and its complications. One inflammatory mediator has come to the fore as a therapeutic target in cardiovascular disease. The experimental and聽clinical evidence reviewed here support interleukin-1 beta (IL-1尾) as both a local vascular and systemic contributor in this regard. Intrinsic vascular wall cells and lesional leukocytes alike can produce this cytokine. Local stimuli in the plaque聽favor...
89 CitationsSource
BackgroundExperimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. MethodsWe conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1尾, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The ...
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BackgroundCoronary artery calcium (CAC) predicts coronary heart disease (CHD) events better than carotid wall plaque presence; however, differences in the utility of CAC burden and carotid plaque b...
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#1Robert W. McGarrah (Duke University)H-Index: 11
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BACKGROUND:Evidence suggests that systemic inflammation may adversely impact HDL function. In this study we sought to evaluate the independent and incremental predictive performance of GlycA-a novel serum inflammatory biomarker that is an aggregate measure of enzymatically glycosylated acute phase proteins-and HDL subclasses on adverse events in a retrospective observational study of a secondary prevention population and to understand a priori defined potential interactions between GlycA and HDL...
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#1Surovi Hazarika (UVA: University of Virginia)H-Index: 5
#2Brian H. Annex (UVA: University of Virginia)H-Index: 48
Background: Peripheral artery disease (PAD) is highly prevalent and there is considerable diversity in the initial clinical manifestation and disease progression among individuals. Currently, there is no ideal biomarker to screen for PAD, to risk stratify patients with PAD, or to monitor therapeutic response to revascularization procedures. Advances in human genetics have markedly enhanced the ability to develop novel diagnostic and therapeutic approaches across a host of human diseases, but suc...
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Abstract The mitral annulus is a fibrous structure that surrounds the mitral valve leaflets and is prone to calcification. Despite its common occurrence, association with cardiovascular morbidity and mortality and relationship with dysfunction of the mitral valve, the pathobiology of mitral annular calcification is incompletely understood. Mitral annular calcification is no longer regarded as a local, chronic and degenerative process resulting in precipitation of calcium and phosphate, but as an...
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