Chromatin three-dimensional interactions mediate genetic effects on gene expression

Science56.90
Volume: 364, Issue: 6439, Pages: 1 - 10
Published: May 3, 2019
Abstract
Studying the genetic basis of gene expression and chromatin organization is key to characterizing the effect of genetic variability on the function and structure of the human genome. Here we unravel how genetic variation perturbs gene regulation using a dataset combining activity of regulatory elements, gene expression, and genetic variants across 317 individuals and two cell types. We show that variability in regulatory activity is structured...
Paper Details
Title
Chromatin three-dimensional interactions mediate genetic effects on gene expression
Published Date
May 3, 2019
Journal
Volume
364
Issue
6439
Pages
1 - 10
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