Concept and benchmarks for assessing narrow‐sense validity of genetic risk score values

Background While higher genetic risk score (GRS) has been statistically associated with increased disease risk (broad‐sense validity), the concept and tools for assessing the validity of reported GRS values from tests (narrow‐sense validity) are underdeveloped. Methods We propose two benchmarks for assessing the narrow‐sense validity of GRS. The baseline benchmark requires that the mean GRS value in a general population approximates 1.0. The...