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Long noncoding RNA/circular noncoding RNA–miRNA–mRNA axes in cardiovascular diseases

Published on Apr 1, 2019in Life Sciences3.45
· DOI :10.1016/j.lfs.2019.04.066
Ming Li , Liwei Duan + 1 AuthorsBin Liu
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Abstract
Abstract Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Non-coding RNAs including long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs) have been reported to participate in pathological developments of CVDs through various mechanisms. Among them, the networks among lncRNAs/circRNAs, miRNAs, and mRNAs have recently attracted attention. Understanding the molecular mechanism could aid the discovery of therapeutic targets or strategies in CVDs including atherosclerosis, myocardial infarction (MI), hypertrophy, heart failure (HF) and cardiomyopathy. In this review, we summarize the latest research involving the lncRNA/circRNA–miRNA–mRNA axis in CVDs, with emphasis on the molecular mechanism.
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Published on Feb 8, 2019in Clinical Epigenetics
Hangyu Wu1
Estimated H-index: 1
(NBU: Ningbo University),
Siyang Wu (NBU: Ningbo University)+ 5 AuthorsShizhong Bu6
Estimated H-index: 6
(NBU: Ningbo University)
Background Circular RNA (circRNA) is involved in the pathological processes of various diseases. CircRNA is more stable than linear RNAs and is expressed in high levels in tissues, making it a better biomarker candidate than linear RNAs. In this study, we aimed to identify potential circRNA biomarkers of gestational diabetes mellitus (GDM).
Published on Aug 1, 2019in Journal of Cellular Physiology4.52
Lili Xiao3
Estimated H-index: 3
,
Yulei Gu1
Estimated H-index: 1
+ 5 AuthorsLing Li14
Estimated H-index: 14
Published on Jul 1, 2019in Journal of Cellular Physiology4.52
Xiaoyan Guo1
Estimated H-index: 1
(Zhengzhou University),
Xiaoguang Wu1
Estimated H-index: 1
(Zhengzhou University)
+ 2 AuthorsJiangtao Cheng1
Estimated H-index: 1
(Zhengzhou University)
Published on Jun 1, 2019in Journal of Cellular Biochemistry3.45
Jing‐jing Wang (Xi'an Jiaotong University), Zi‐dong Bie , Chao‐feng Sun1
Estimated H-index: 1
(Xi'an Jiaotong University)
Dongying Zhang1
Estimated H-index: 1
(Nanjing Medical University),
Bingjian Wang (Nanjing Medical University)+ 3 AuthorsXiwen Zhang2
Estimated H-index: 2
(Nanjing Medical University)
Myocardial infarction (MI) is a cardiovascular disease with high morbidity and mortality. In this study, we focused on exploring the roles and underlying regulatory mechanisms of Hox transcript antisense intergenic RNA (HOTAIR) and miR-519d-3p in myocardial infarction. To comprehensively understand the role of microRNA in MI rat, we construct MI rat model by permanent ligation of the left anterior descending (LAD) coronary artery. Cardiac troponin I and creatine kinase-MB concentration measured ...
Published on May 1, 2019in Journal of Cellular Biochemistry3.45
Jing Zhou1
Estimated H-index: 1
(Xi'an Jiaotong University),
Yu Zhou1
Estimated H-index: 1
,
Cong‐xia Wang1
Estimated H-index: 1
(Xi'an Jiaotong University)
Published on Apr 1, 2019in Journal of Cellular Biochemistry3.45
Qiuyun Wang1
Estimated H-index: 1
(SJTU: Shanghai Jiao Tong University),
Guoping Lu3
Estimated H-index: 3
(SJTU: Shanghai Jiao Tong University),
Zhenyue Chen3
Estimated H-index: 3
(SJTU: Shanghai Jiao Tong University)
Published on Apr 1, 2019in Journal of Cellular Physiology4.52
Lu Gao4
Estimated H-index: 4
(Zhengzhou University),
Xiaofang Wang (Zhengzhou University)+ 8 AuthorsYuan Liu2
Estimated H-index: 2
(Zhengzhou University)
Published on Mar 1, 2019in Journal of Cellular Physiology4.52
Songqun Huang1
Estimated H-index: 1
('SMMU': Second Military Medical University),
Liang Zhang2
Estimated H-index: 2
('SMMU': Second Military Medical University)
+ 5 AuthorsXianxian Zhao14
Estimated H-index: 14
('SMMU': Second Military Medical University)
Abstract Cardiac fibrosis is a pathological remodeling response to myocardial infarction (MI) and impairs cardiac contractility. Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is increased in patients with MI. However, the functions of MALAT1 in cardiac fibrosis have not been elucidated. This study elucidates the roles of MALAT1 in MI and the underlying mechanisms. The MI model was established by artificial coronary artery occlusion in mice. Western b...
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