Multiomics Assessment of Gene Expression in a Clinical Strain of CTX-M-15-Producing ST131 Escherichia coli

Extended spectrum beta-lactamase (ESBL)-producing Escherichia coli strain C999 was isolated of a patient with urinary tract infection. Previous genotyping indicated that this strain presented a multidrug resistant phenotype and carried the genes of the ESBL CTX-M-15, in addition to those of TEM-1 and OXA-1 enzymes. The whole-cell proteome, and the membrane, cytoplasmic, periplasmic and extracellular sub-proteomes of C999 were obtained in this...