Melatonin loaded lipid enriched chitosan microspheres – Hybrid dressing for moderate exuding wounds

The aim of this study was to develop nanostructured lipid carrier (NLC)-loaded chitosan-based microspheres as innovative dry powder wound dressing, with melatonin incorporated in both, NLC and chitosan matrix of the proposed hybrid system. Melatonin-loaded NLCs were prepared by a hot homogenization technique, while NLC-loaded microspheres were produced by a spray-drying method. To optimize the critical formulation and process parameters for both...