B cell depletion with ublituximab reshapes the T cell profile in multiple sclerosis patients
Abstract
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, thought to be mediated by myelin-specific CD4+ T cells. However, B cell depletion has proven to be an effective therapy for MS, but the mechanism is not well understood. This study was designed to determine how B cell depletion changes lymphocyte profiles. During a phase IIa clinical trial with ublituximab, a novel CD20 antibody, blood was collected from 48 MS...
Paper Details
Title
B cell depletion with ublituximab reshapes the T cell profile in multiple sclerosis patients
Published Date
Jul 1, 2019
Journal
Volume
332
Pages
187 - 197
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