The Hard-To-Close Window of T-Type Calcium Channels

T-Type Ca2+ channels (TTCCs) play a role in membrane excitability, and the development of selective TTCC pharmacological blockers for neurological conditions such as pain, epilepsy, tremor, ataxia, and insomnia is an active area of research. TTCCs also enable sustained Ca2+ entry (known as window currents), which facilitates the G1–S transition and appears necessary for the survival of proliferating cells. Pharmacological targeting of TTCCs is...