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Coronary microvascular dysfunction is associated with cardiac time intervals in women with angina and no obstructive coronary artery disease: An iPOWER substudy

Published on Jun 1, 2019in Echocardiography-a Journal of Cardiovascular Ultrasound and Allied Techniques1.287
· DOI :10.1111/echo.14356
Adam Pena7
Estimated H-index: 7
,
Marie Mide Michelsen8
Estimated H-index: 8
+ 7 AuthorsEva Prescott43
Estimated H-index: 43
Abstract
  • References (32)
  • Citations (0)
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References32
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#1Viviany R. Taqueti (Brigham and Women's Hospital)H-Index: 19
#2Scott D. Solomon (Brigham and Women's Hospital)H-Index: 107
Last. Marcelo F. Di Carli (Brigham and Women's Hospital)H-Index: 66
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#1Matthew C. Konerman (UM: University of Michigan)H-Index: 3
#2Joshua C. Greenberg (HFH: Henry Ford Hospital)H-Index: 1
Last. Scott L. Hummel (UM: University of Michigan)H-Index: 14
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Abstract Introduction Coronary microvascular dysfunction (MVD) may contribute to the pathogenesis of heart failure with preserved ejection fraction (HFpEF). Using myocardial flow reserve (MFR) measured by positron emission tomography (PET) as an assessment of microvascular function, we hypothesized that abnormal MFR is associated with LV diastolic dysfunction (DD) and reduced LV and LA strain in patients with risk factors for HFpEF and normal epicardial perfusion on cardiac PET. Methods and Resu...
7 CitationsSource
#2Naja Dam MygindH-Index: 11
Last. Eva PrescottH-Index: 2
view all 4 authors...
4 CitationsSource
#1Marie Mide Michelsen (UCPH: University of Copenhagen)H-Index: 8
#2Naja Dam Mygind (UCPH: University of Copenhagen)H-Index: 11
Last. Eva Prescott (UCPH: University of Copenhagen)H-Index: 43
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Abstract Background Coronary microvascular function can be assessed by transthoracic Doppler echocardiography as a coronary flow velocity reserve (TTDE CFVR) and by positron emission tomography as a myocardial blood flow reserve (PET MBFR). PET MBFR is regarded the noninvasive reference standard for measuring coronary microvascular function but has limited availability. We compared TTDE CFVR with PET MBFR in women with angina pectoris and no obstructive coronary artery disease and assessed repea...
14 CitationsSource
#1Piotr PonikowskiH-Index: 106
#2Adriaan A. VoorsH-Index: 82
Last. P. van der MeerH-Index: 42
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ACC/AHA : American College of Cardiology/American Heart Association ACCF/AHA : American College of Cardiology Foundation/American Heart Association ACE : angiotensin-converting enzyme ACEI : angiotensin-converting enzyme inhibitor ACS : acute coronary syndrome AF : atrial fibrillation
2,864 CitationsSource
#1Marie Mide Michelsen (UCPH: University of Copenhagen)H-Index: 8
#2Adam Pena (UCPH: University of Copenhagen)H-Index: 7
Last. Eva Prescott (UCPH: University of Copenhagen)H-Index: 43
view all 10 authors...
Background Coronary flow velocity reserve (CFVR) measured by transthoracic Doppler echocardiography is a noninvasive measure of microvascular function, but it has not achieved widespread use, mainly because of concerns of validity and feasibility. The aim of this study was to describe the feasibility and factors associated with the quality of CFVR obtained in a large prospective study of women suspected of having microvascular disease. Methods Women with angina-like chest pain and no obstructive...
22 CitationsSource
#2Rasmus MogelvangH-Index: 25
Last. Jan Skov JensenH-Index: 50
view all 6 authors...
Purpose To define normal values of the cardiac time intervals obtained by tissue Doppler imaging (TDI) M-mode through the mitral valve (MV). Furthermore, to evaluate the association of the myocardial performance index (MPI) obtained by TDI M-mode (MPITDI) and the conventional method of obtaining MPI (MPIConv), with established echocardiographic and invasive measures of systolic and diastolic function.
9 CitationsSource
#1Jaskanwal D. Sara (UR: University of Rochester)H-Index: 5
#2R. Jay Widmer (UR: University of Rochester)H-Index: 13
Last. Amir Lerman (UR: University of Rochester)H-Index: 17
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Abstract Objectives This study assessed the prevalence of coronary microvascular abnormalities in patients presenting with chest pain and nonobstructive coronary artery disease (CAD). Background Coronary microvascular abnormalities mediate ischemia and can lead to an increased risk of cardiovascular events. Methods Using an intracoronary Doppler guidewire, endothelial-dependent microvascular function was examined by evaluating changes in coronary blood flow in response to acetylcholine, whereas ...
89 CitationsSource
#1Frank A. Flachskampf (Uppsala University)H-Index: 41
#2Tor Biering-Sørensen (Brigham and Women's Hospital)H-Index: 18
Last. Otto A. Smiseth (Oslo University Hospital)H-Index: 57
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Left ventricular diastolic dysfunction in clinical practice is generally diagnosed by imaging. Recognition of heart failure with preserved ejection fraction has increased interest in the detection and evaluation of this condition and prompted an improved understanding of the strengths and weaknesses of different imaging modalities for evaluating diastolic dysfunction. This review briefly provides the pathophysiological background for current clinical and experimental imaging parameters of diasto...
69 CitationsSource
#1Takayuki Kawata (Juntendo University)H-Index: 10
#2Masao Daimon (Juntendo University)H-Index: 21
Last. Hiroyuki Daida (Juntendo University)H-Index: 43
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Background Left ventricular (LV) diastolic dysfunction is known as an early marker of myocardial alterations in patients with diabetes. Because microvascular disease has been regarded as an important cause of heart failure or diastolic dysfunction in diabetic patients, we tested the hypothesis that coronary flow reserve (CFR), which reflects coronary microvascular function, is associated with LV diastolic dysfunction in patients with type 2 diabetes.
26 CitationsSource
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