Association of Duration and Type of Surgical Prophylaxis With Antimicrobial-Associated Adverse Events

The benefits of antimicrobial prophylaxis are limited to the first 24 hours postoperatively. Little is known about the harms associated with continuing antimicrobial prophylaxis after skin closure.To characterize the association of type and duration of prophylaxis with surgical site infection (SSI), acute kidney injury (AKI), and Clostridium difficile infection.In this multicenter, national retrospective cohort study, all patients within the...