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Antioxidant and Anti-Diabetic Functions of a Polyphenol-Rich Sugarcane Extract.

Published on Apr 22, 2019in Journal of The American College of Nutrition2.08
· DOI :10.1080/07315724.2019.1587323
Jin Ji2
Estimated H-index: 2
,
Xin Yang1
Estimated H-index: 1
+ 2 AuthorsBarry Kitchen2
Estimated H-index: 2
Abstract
AbstractObjectives: Dysfunctional metabolism of carbohydrates is a fundamental component of many dietary-related disorders. It has been hypothesized that plant extracts containing high levels of antioxidants may have the ability to stabilize carbohydrate regulation. The aim of this study was to assess the effects of a polyphenol-rich sugarcane extract on cellular pathways related to carbohydrate metabolism.Methods: We evaluated the antioxidant activity of a polyphenol-rich sugarcane extract obtained by a patented hydrophobic extract process and its therapeutic potential to regulate carbohydrate metabolism and protect against metabolic disorders such as type 2 diabetes.Results: Quantitative analytical studies support that the polyphenol-rich sugarcane extract has a high concentration of polyphenols and antioxidant compounds. The follow-up cellular studies via Caco-2 cells and dysfunctional β-cell models suggested that the polyphenol-rich sugarcane extract may help deter glucose and fructose uptake in intes...
  • References (27)
  • Citations (3)
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References27
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#1Dabeen Lee (Kookmin University)H-Index: 4
#2Jee-Young Imm (Kookmin University)H-Index: 12
The antiobesity potential of tricin, a methylated cereal flavonoid, was examined using a high-fat-diet-induced obese mice model. The body weight (P < 0.01) and body fat mass (P < 0.05) were significantly decreased in the high-dose tricin supplementation group (TH: 200 mg/kg diet) in comparison to the high fat diet control group (CON) after a 12-week feeding trial. The serum (60.9 ± 2.09 mg/dL) and hepatic triglyceride levels (45.3 ± 4.42 nmol/mg protein) in the TH group were significantly decrea...
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#1Nelson Andrade (University of Porto)H-Index: 3
#2João R. Araújo (University of Porto)H-Index: 18
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Abstract Intake of high-fructose products is associated with metabolic syndrome development. We investigated if dietary polyphenols can interfere with fructose absorption by the human intestinal epithelial Caco-2 cell line. Acutely, several polyphenols induced a significant decrease (15–20%) in 14 C-fructose uptake. Chronically, 14 C-fructose uptake was also affected by polyphenols; quercetin, chrysin and apigenin (100 µM) were the most effective (±25% decrease). These compounds (100 µM) appear ...
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#2Alison G. WrightH-Index: 2
Last. Leodevico L. Ilag (University of Melbourne)H-Index: 8
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Purpose A phytochemical- and mineral-rich filtered sugarcane molasses concentrate (FMC), when added to carbohydrate-containing foods as a functional ingredient, lowers postprandial blood glucose and insulin responses. We hypothesised that this beneficial effect would also occur if FMC was administered as an oral supplement taken before a meal.
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AbstractThe impact of sugar consumption on health continues to be a controversial topic. The objective of this review is to discuss the evidence and lack of evidence that allows the controversy to continue, and why resolution of the controversy is important. There are plausible mechanisms and research evidence that supports the suggestion that consumption of excess sugar promotes the development of cardiovascular disease (CVD) and type 2 diabetes (T2DM) both directly and indirectly. The direct p...
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This study compared the ability of nine culinary plant extracts containing a wide array of phytochemicals to inhibit fructose uptake and then explored the involvement of intestinal fructose transporters and phytochemicals for selected samples. The chemical signature was characterized by high performance liquid chromatography with mass spectrometry. Inhibition of [14C]-fructose uptake was tested by using human intestinal Caco-2 cells. Then, the relative contribution of the two apical-facing intes...
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Sugarcane (Saccharum officinarum Linn.) is an important perennial grass of Poaceae family, indigenous to tropical South Asia and Southeast Asia. It is cultivated worldwide due to the economical and medicinal value of its high yielding products. Sugarcane juice is well known as a raw material for the production of refined sugar and its wax is considered as a potential substitute for the expensive carnauba wax, which is of cosmetic and pharmaceutical interest. Refined sugar is the primary product ...
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Recent publications suggest that high dietary fructose might play a significant role in cancer metabolism and can exacerbate a number of aspects of metabolic syndrome. Addressing the role that fructose plays in human health is a controversial question and requires a detailed understanding of many factors including the mechanism of fructose transport into healthy and diseased cells. Fructose transport into cells is thought to be largely mediated by the passive hexose transporters Glut2 and Glut5....
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#1Marlon E. Cerf (South African Medical Research Council)H-Index: 14
Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states induce hyperglycemia and therefore increase insulin demand. Beta cell dysfunction results from inadequate glucose sensing to stimulate insulin secretion therefore elevated glucose concentrations prevail. Persistently elevated glucose concentrations above the physiological range result in the manifestation of hyper...
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Commercial whole coffee fruit extracts and powder samples were analyzed for chlorogenic acids (CGA), caffeine and antioxidant activities. CGA and caffeine were characterized by LC−MSn and HPLC accordingly, and quantified by UV absorbance. ORAC, HORAC, NORAC, SORAC and SOAC (antioxidant capacities) were assessed. Three caffeoylquinic acids, three feruloylquinic acids, three dicaffeoylquinic acids, one p-coumaroylquinic acid, two caffeoylferuloylquinic acids and three putative chlorogenic lactones...
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Obesity and insulin resistance have been linked to a low-grade chronic inflammatory response characterized by increased macrophage infiltration, altered cytokine production and activation of inflammatory signaling pathway in adipose tissue. Pharmacological agents and natural products that are capable of reducing inflammatory activity possess anti-diabetic properties. Luteolin, a naturally occurring flavonoid, has been demonstrated to inhibit lipopolysaccharide-induced tumor necrosis factor-α (TN...
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Abstract Evidence suggests that enhanced oxidative stress and mild, chronic inflammation is associated with the onset and progression of some neurological disorders. Hypothesis A polyphenol rich sugarcane extract may be active in protecting against this inflammation and neurological degeneration. Study design A series of cell culture strains and in vitro gene expression studies were used to understand the neuroprotective activity. Methods Extract was prepared according to a patented extraction p...
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#1Myrna A. Deseo (La Trobe University)H-Index: 1
#2Aaron ElkinsH-Index: 1
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Abstract The antioxidant activity of sugarcane molasses ethanol extract (ME) and its fraction (ME-RBF) was evaluated using ABTS, ORAC 6.0 and CAA assays and ME-RBF demonstrated 26-fold, 12-fold and 2-fold higher values, respectively than ME. Likewise, total polyphenol and flavonoid concentration in ME-RBF are more than 10-fold higher than ME, that suggested antioxidant activity is correlated with polyphenol composition. Quantitative analysis of 13 polyphenols (chlorogenic acid, caffeic acid, sin...
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Increasing evidence suggests that environmental stress, such as UV radiation, generates reactive oxygen and nitrogen species in skin cells, leading to histochemical changes including skin disorders and aging, hyper pigmentation, and increased formation of wrinkles. Besides the defensive system in skin composed of vitamins and intrinsic antioxidant enzymes, topical and skin conditioning products have been used commonly to eradicate or eliminate these skin ailments. Among various ingredients provi...
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