Endothelium‐dependent and endothelium‐independent effects of 1‐nitro‐2‐propylbenzene on rat aorta

A group of nitro compounds contains a benzene ring in a short aliphatic chain with the NO 2 group, property that supposedly favors its vasodilator profile. In this study, we evaluated in isolated rat aorta the effects of 1‐nitro‐2‐propylbenzene ( NPB ), a nitro compound containing the NO 2 in the aromatic ring. In aorta precontracted with KC l, NPB (1‐3000 μ m ) induced full endothelium‐independent relaxation. In endothelium‐intact preparations,...