Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate
Abstract
Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte...
Paper Details
Title
Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate
Published Date
Apr 25, 2019
Journal
Volume
29
Issue
6
Pages
486 - 501
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Notes
History