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Dissociable effects of cannabis with and without cannabidiol on the human brain’s resting-state functional connectivity:

Published on Apr 23, 2019in Journal of Psychopharmacology4.22
· DOI :10.1177/0269881119841568
Matthew B. Wall19
Estimated H-index: 19
(UCL: University College London),
Rebecca Anne Pope3
Estimated H-index: 3
(UCL: University College London)
+ 10 AuthorsH. Valerie Curran41
Estimated H-index: 41
(UCL: University College London)
Abstract
Background:Two major constituents of cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the main psychoactive component; CBD may buffer the user against the harmful effects of THC.Aims:We examined the effects of two strains of cannabis and placebo on the human brain’s resting-state networks using fMRI.Methods:Seventeen healthy volunteers (experienced with cannabis, but not regular users) underwent three drug treatments and scanning sessions. Treatments were cannabis containing THC (Cann−CBD; 8 mg THC), cannabis containing THC with CBD (Cann+CBD; 8 mg THC + 10 mg CBD), and matched placebo cannabis. Seed-based resting-state functional connectivity analyses were performed on three brain networks: the default mode (DMN; defined by positive connectivity with the posterior cingulate cortex: PCC+), executive control (ECN; defined by negative connectivity with the posterior cingulate cortex: PCC−) and salience (SAL; defined by positive connectivity with the anterior insula: AI+) network.Resu...
  • References (59)
  • Citations (1)
References59
Newest
#1Lysia Demetriou (Hammersmith Hospital)H-Index: 1
#2Oliwia S Kowalczyk (RHUL: Royal Holloway, University of London)H-Index: 1
Last.Matthew B. Wall (UCL: University College London)H-Index: 19
view all 6 authors...
#1Tom P. Freeman (UCL: University College London)H-Index: 20
#2Rebecca Anne Pope (UCL: University College London)H-Index: 3
Last.H. Valerie Curran (UCL: University College London)H-Index: 41
view all 13 authors...
#1Claire Mokrysz (UCL: University College London)H-Index: 9
#2Tom P. Freeman (UCL: University College London)H-Index: 20
Last.Hv Curran (UCL: University College London)H-Index: 22
view all 5 authors...
#1Will Lawn (UCL: University College London)H-Index: 8
#2Tom P. Freeman (UCL: University College London)H-Index: 20
Last.H. Valerie Curran (UCL: University College London)H-Index: 41
view all 14 authors...
#1Mendel Kaelen (Imperial College London)H-Index: 15
#2Leor Roseman (Imperial College London)H-Index: 11
Last.Robin L. Carhart-Harris (Imperial College London)H-Index: 26
view all 15 authors...
#1H. Valerie Curran (UCL: University College London)H-Index: 41
#2Tom P. FreemanH-Index: 20
Last.Loren H. Parsons (Scripps Research Institute)H-Index: 56
view all 6 authors...
Cited By1
Newest
#1Liangsuo Ma (VCU: Virginia Commonwealth University)H-Index: 9
#2Marco Giuseppe Del Buono (UCSC: Catholic University of the Sacred Heart)H-Index: 4
Last.F. Gerard Moeller (VCU: Virginia Commonwealth University)H-Index: 55
view all 3 authors...
#1Edward James (Cardiff University)H-Index: 1
#2Thomas L Robertshaw (Cardiff University)H-Index: 1
Last.Andrew Paul Smith (Cardiff University)H-Index: 51
view all 0 authors...
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