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Dissociable effects of cannabis with and without cannabidiol on the human brain’s resting-state functional connectivity:

Published on Apr 23, 2019in Journal of Psychopharmacology 4.22
· DOI :10.1177/0269881119841568
Matthew B. Wall19
Estimated H-index: 19
(UCL: University College London),
Rebecca Anne Pope3
Estimated H-index: 3
(UCL: University College London)
+ 10 AuthorsH. Valerie Curran41
Estimated H-index: 41
(UCL: University College London)
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Abstract
Background:Two major constituents of cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the main psychoactive component; CBD may buffer the user against the harmful effects of THC.Aims:We examined the effects of two strains of cannabis and placebo on the human brain’s resting-state networks using fMRI.Methods:Seventeen healthy volunteers (experienced with cannabis, but not regular users) underwent three drug treatments and scanning sessions. Treatments were cannabis containing THC (Cann−CBD; 8 mg THC), cannabis containing THC with CBD (Cann+CBD; 8 mg THC + 10 mg CBD), and matched placebo cannabis. Seed-based resting-state functional connectivity analyses were performed on three brain networks: the default mode (DMN; defined by positive connectivity with the posterior cingulate cortex: PCC+), executive control (ECN; defined by negative connectivity with the posterior cingulate cortex: PCC−) and salience (SAL; defined by positive connectivity with the anterior insula: AI+) network.Resu...
  • References (59)
  • Citations (1)
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References59
Newest
Published on Oct 18, 2018in JCI insight
Alexander Comninos15
Estimated H-index: 15
,
Lysia Demetriou3
Estimated H-index: 3
+ 19 AuthorsAli Abbara13
Estimated H-index: 13
Published on Oct 1, 2018in Psychological Medicine 5.64
Tom P. Freeman20
Estimated H-index: 20
,
Pol van der P12
Estimated H-index: 12
+ 8 AuthorsRaymond J.M. Niesink27
Estimated H-index: 27
Background The number of people entering specialist drug treatment for cannabis problems has increased considerably in recent years. The reasons for this are unclear, but rising cannabis potency could be a contributing factor. Methods Cannabis potency data were obtained from an ongoing monitoring programme in the Netherlands. We analysed concentrations of δ -9-tetrahydrocannabinol (THC) from the most popular variety of domestic herbal cannabis sold in each retail outlet (2000–2015). Mixed effect...
Published on Aug 1, 2018in NeuroImage 5.81
Lysia Demetriou1
Estimated H-index: 1
(Hammersmith Hospital),
Oliwia S Kowalczyk1
Estimated H-index: 1
(RHUL: Royal Holloway, University of London)
+ 3 AuthorsMatthew B. Wall19
Estimated H-index: 19
(UCL: University College London)
Abstract Accelerated functional Magnetic Resonance Imaging (fMRI) with ‘multiband’ protocols is now relatively widespread. These protocols can be used to dramatically reduce the repetition time (TR) and produce a time-series sampled at a higher temporal resolution, which may produce benefits in the statistical methods typically used to analyse fMRI data. We tested the effects of higher temporal resolutions for fMRI on statistical outcome measures in a comprehensive manner on two different MRI sc...
Published on Jul 1, 2018in European Neuropsychopharmacology 4.47
Oliver Grimm26
Estimated H-index: 26
(Goethe University Frankfurt),
Martin Löffler3
Estimated H-index: 3
(Heidelberg University)
+ 4 AuthorsHerta Flor84
Estimated H-index: 84
(Heidelberg University)
Abstract Tetrahydrocannabinol (THC) and Cannabidiol (CBD) are two substances from cannabis sativa that have beenimplicated in the treatment of mental and neurological disorders. We concentrated on a previously validated neuroimaging phenotype, fronto-striatal connectivity across different striatal seeds, because of this loop's relevance to executive functioning, decision making, salience generation and motivation and its link to various neuropsychiatric conditions. Therefore, we studied the effe...
Published on Jan 1, 2018in The International Journal of Neuropsychopharmacology 4.21
Tom P. Freeman20
Estimated H-index: 20
(UCL: University College London),
Rebecca Anne Pope3
Estimated H-index: 3
(UCL: University College London)
+ 10 AuthorsMichael A P Bloomfield8
Estimated H-index: 8
(UCL: University College London)
Background: Despite the current shift towards permissive cannabis policies, few studies have investigated the pleasurable effects users seek. Here, we investigate the effects of cannabis on listening to music, a rewarding activity that frequently occurs in the context of recreational cannabis use. We additionally tested how these effects are influenced by cannabidiol, which may offset cannabis-related harms. Methods: Across 3 sessions, 16 cannabis users inhaled cannabis with cannabidiol, cannabi...
Published on Dec 1, 2016in Brain Imaging and Behavior 3.42
Johannes G. Ramaekers40
Estimated H-index: 40
(UM: Maastricht University),
J.H.P. van Wel5
Estimated H-index: 5
(UM: Maastricht University)
+ 7 AuthorsRobbert Jan Verkes20
Estimated H-index: 20
(Radboud University Nijmegen)
The dopamine β-hydroxylase (DβH) enzyme transforms dopamine into noradrenaline. We hypothesized that individuals with low activity DBH genotypes (rs1611115 CT/TT) are more sensitive to the influence of cannabis and cocaine on cognitive impulse control and functional connectivity in the limbic ‘reward’ circuit because they experience a drug induced hyperdopaminergic state compared to individuals with high activity DBH genotypes (rs1611115 CC). Regular drug users (N = 122) received acute doses of ...
Published on Nov 1, 2016in Translational Psychiatry 5.18
Claire Mokrysz9
Estimated H-index: 9
(UCL: University College London),
Tom P. Freeman20
Estimated H-index: 20
(UCL: University College London)
+ 2 AuthorsHv Curran22
Estimated H-index: 22
(UCL: University College London)
Are adolescents more vulnerable to the harmful effects of cannabis than adults? A placebo-controlled study in human males
Published on Oct 1, 2016in Psychopharmacology 3.42
Will Lawn8
Estimated H-index: 8
(UCL: University College London),
Tom P. Freeman20
Estimated H-index: 20
(UCL: University College London)
+ 11 AuthorsMichael A P Bloomfield8
Estimated H-index: 8
(UCL: University College London)
Rationale Anecdotally, both acute and chronic cannabis use have been associated with apathy, amotivation, and other reward processing deficits. To date, empirical support for these effects is limited, and no previous studies have assessed both acute effects of Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), as well as associations with cannabis dependence.
Published on Jul 1, 2016in European Neuropsychopharmacology 4.47
Mendel Kaelen15
Estimated H-index: 15
(Imperial College London),
Leor Roseman11
Estimated H-index: 11
(Imperial College London)
+ 12 AuthorsLuke Williams3
Estimated H-index: 3
(Imperial College London)
Abstract Psychedelic drugs such as lysergic acid diethylamide (LSD) were used extensively in psychiatry in the past and their therapeutic potential is beginning to be re-examined today. Psychedelic psychotherapy typically involves a patient lying with their eyes-closed during peak drug effects, while listening to music and being supervised by trained psychotherapists. In this context, music is considered to be a key element in the therapeutic model; working in synergy with the drug to evoke ther...
Published on May 1, 2016in Nature Reviews Neuroscience 33.16
H. Valerie Curran41
Estimated H-index: 41
(UCL: University College London),
Tom P. Freeman20
Estimated H-index: 20
+ 3 AuthorsLoren H. Parsons56
Estimated H-index: 56
(Scripps Research Institute)
In an increasing number of states and countries, cannabis now stands poised to join alcohol and tobacco as a legal drug. Quantifying the relative adverse and beneficial effects of cannabis and its constituent cannabinoids should therefore be prioritized. Whereas newspaper headlines have focused on links between cannabis and psychosis, less attention has been paid to the much more common problem of cannabis addiction. Certain cognitive changes have also been attributed to cannabis use, although t...
Cited By1
Newest
Published on Jun 10, 2019in BMJ 27.60
David B Menkes17
Estimated H-index: 17
(University of Auckland)
Nutt describes some of the interesting history of cannabis as medicine and notes the wide variety of maladies for which it is claimed to be useful.1 His enthusiasm for medical cannabis extends to a call for its efficacy and adverse effects to be assessed …
Published in Current Cardiology Reports 2.40
Liangsuo Ma9
Estimated H-index: 9
(VCU: Virginia Commonwealth University),
Marco Giuseppe Del Buono4
Estimated H-index: 4
(UCSC: Catholic University of the Sacred Heart),
F. Gerard Moeller55
Estimated H-index: 55
(VCU: Virginia Commonwealth University)
Purpose of Review Recently, an association between cannabis use and Takotsubo (stress) cardiomyopathy (TTC) has been shown. With the current trend of legalization of cannabis, it is important to understand brain effects of cannabis use that could lead to cardiac disease, such as TTC. Here we review recent brain imaging studies in order to search for the evidence supporting the association between cannabis use, stress, and TTC.