A redox sensitivity-based method to quantify both pentameric and monomeric C-reactive protein in a single assay
Abstract
C-reactive protein (CRP) can exist in both pentameric (pCRP) and monomeric conformation (mCRP). Though serum pCRP is an established marker of inflammation, the diagnostic significance of mCRP remains unknown largely due to the lack of a reliable assay. The power and specificity of antibody-based assays are limited by the antibody reagents used and by the degree of cross-reactivity that may exist in detecting each antigen, as mCRP is known to be...
Paper Details
Title
A redox sensitivity-based method to quantify both pentameric and monomeric C-reactive protein in a single assay
Published Date
Jul 1, 2019
Volume
470
Pages
40 - 45
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