Isolation and enrichment of mouse insulin-specific CD4+ T regulatory cells
Abstract
Polyclonal T regulatory cells (Treg - CD4+CD25+CD127lowFoxp3+) are used in several protocols for the treatment of type 1 diabetes (T1D), multiple sclerosis and graft-versus host disease in clinical trials. However, general opinion is that autoantigen-specific Treg could be more efficient in autoimmunity suppression due to their direct effect on pathogenic autoantigen-specific effector T cells. This study describes isolation and expansion of...
Paper Details
Title
Isolation and enrichment of mouse insulin-specific CD4+ T regulatory cells
Published Date
Jul 1, 2019
Volume
470
Pages
46 - 54
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