Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
Abstract
We performed the first proteogenomic study on a prospectively collected colon cancer cohort. Comparative proteomic and phosphoproteomic analysis of paired tumor and normal adjacent tissues produced a catalog of colon cancer-associated proteins and phosphosites, including known and putative new biomarkers, drug targets, and cancer/testis antigens. Proteogenomic integration not only prioritized genomically inferred targets, such as copy-number...
Paper Details
Title
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
Published Date
May 1, 2019
Journal
Volume
177
Issue
4
Pages
1035 - 1049.e19
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