Novel blood pressure targets in patients with high-normal levels and grade 1 hypertension: Room for monotherapy?

The 2018 European and 2017 American guidelines recommend to start antihypertensive treatment with combinations of two or more drugs in most hypertensive patients, as a consequence of the suggested more ambitious blood pressure (BP) targets (systolic BP between 130 and 120 mmHg in most patients, diastolic BP between 80 and 70 mmHg).Monotherapy, however, is still suggested as first choice in some specific classes of patients.In this article, we...