Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease
Abstract
Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychiatric, metabolic, and other diseases. Extending our recent findings of oscillating cytosine modifications (osc-modCs) in mice, in this study, we show that osc-modCs are also prevalent in human neutrophils. Osc-modCs may play a role in gene regulation, can...
Paper Details
Title
Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease
Published Date
Jan 3, 2019
Journal
Volume
20
Issue
1
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