MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation
Abstract
Actin cytoskeleton is well-known for providing structural/mechanical support, but whether and how it regulates chromatin and cell fate reprogramming is far less clear. Here, we report that MKL1, the key transcriptional co-activator of many actin cytoskeletal genes, regulates genomic accessibility and cell fate reprogramming. The MKL1-actin pathway weakens during somatic cell reprogramming by pluripotency transcription factors. Cells that...
Paper Details
Title
MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation
Published Date
Apr 12, 2019
Journal
Volume
10
Issue
1
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