The Role of EBV LMP1 and LMP2 in B-cell Lymphoma
Published: Feb 17, 2004
Abstract
The latent membrane proteins (LMP1 and LMP2) of Epstein-Barr virus (EBV) both impinge upon multiple cellular signalling pathways. LMP1, a viral onco-protein, can mimic a constitutively activated CD40 receptor in culture, activating NF-kB and JNK. Using EµLMP1 transgenic mice we find that some CD40 activities can be restored by LMP1 in CD40 null mice, in particular immunoglobulin isotype switching.
We have previously shown that LMP2A allows the...
Paper Details
Title
The Role of EBV LMP1 and LMP2 in B-cell Lymphoma
Published Date
Feb 17, 2004
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