Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses

Volume: 5, Issue: 1
Published: Apr 16, 2019
Abstract
The isolation of human monoclonal antibodies with broadly neutralizing breadth can provide a promising countermeasure for influenza A viruses infection. Most broadly neutralizing antibodies against influenza A viruses bind to the conserved stem region or the receptor-binding cavity of hemagglutinin and the interaction is dominated by the heavy chain. The light chain, however, contributes few or no direct contacts to the antigen. Here we report...
Paper Details
Title
Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses
Published Date
Apr 16, 2019
Volume
5
Issue
1
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