Quality and quantity control of gene expression by nonsense-mediated mRNA decay
Volume: 20, Issue: 7, Pages: 406 - 420
Published: Apr 16, 2019
Abstract
Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most evolutionarily conserved cellular quality control mechanisms. Although NMD was first found to target one-third of mutated, disease-causing mRNAs, it is now known to also target ~10% of unmutated mammalian mRNAs to facilitate appropriate cellular responses - adaptation, differentiation or death - to environmental changes. Mutations in NMD genes in humans are associated...
Paper Details
Title
Quality and quantity control of gene expression by nonsense-mediated mRNA decay
Published Date
Apr 16, 2019
Volume
20
Issue
7
Pages
406 - 420
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