CRISPR/Cas-Mediated Base Editing: Technical Considerations and Practical Applications.
Abstract
Genome editing with CRISPR/Cas has rapidly gained popularity. Base editing, a new CRISPR/Cas-based approach, can precisely convert one nucleotide to another in DNA or RNA without inducing a double-strand DNA break (DSB). A combination of catalytically impaired nuclease variants with different deaminases has yielded diverse base-editing platforms that aim to address the key limitations such as specificity, protospacer adjacent motif (PAM)...
Paper Details
Title
CRISPR/Cas-Mediated Base Editing: Technical Considerations and Practical Applications.
Published Date
Oct 1, 2019
Journal
Volume
37
Issue
10
Pages
1121 - 1142
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