Increasing the specificity of CRISPR systems with engineered RNA secondary structures
Abstract
CRISPR (clustered regularly interspaced short palindromic repeat) systems have been broadly adopted for basic science, biotechnology, and gene and cell therapy. In some cases, these bacterial nucleases have demonstrated off-target activity. This creates a potential hazard for therapeutic applications and could confound results in biological research. Therefore, improving the precision of these nucleases is of broad interest. Here we show that...
Paper Details
Title
Increasing the specificity of CRISPR systems with engineered RNA secondary structures
Published Date
Apr 15, 2019
Journal
Volume
37
Issue
6
Pages
657 - 666
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