Engineered Passive Potassium Conductance in the KR2 Sodium Pump

Volume: 116, Issue: 10, Pages: 1941 - 1951
Published: May 1, 2019
Abstract
Light-driven sodium pumps (NaRs) are microbial rhodopsins that utilize light energy to actively transport sodium ions out of the cell. Here, we used targeted mutagenesis and electrophysiological methods in living cells to demonstrate that NaRs can be converted into light-activated cation channels by molecular engineering. Specifically, introduction of the R109Q mutation into the sodium ion pump of Dokdonia eikasta (KR2) results in passive ion...
Paper Details
Title
Engineered Passive Potassium Conductance in the KR2 Sodium Pump
Published Date
May 1, 2019
Volume
116
Issue
10
Pages
1941 - 1951
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