TLR4-dependent signaling drives extracellular catabolism of low-density lipoprotein aggregates
Abstract
null Objective null Aggregation and modification of low-density lipoproteins (LDL) promotes their retention and accumulation in the arteries. This is a critical initiating factor during atherosclerosis. Macrophage catabolism of aggregated LDL (agLDL) occurs using a specialized extracellular, hydrolytic compartment, the lysosomal synapse (LS). Compartment formation by local actin polymerization and delivery of lysosomal contents by exocytosis...
Paper Details
Title
TLR4-dependent signaling drives extracellular catabolism of low-density lipoprotein aggregates
DOI
Published Date
Apr 15, 2019
Journal
Pages
610162
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