A yeast selection system for the detection of proteasomal activation.

Volume: 31, Issue: 11, Pages: 437 - 445
Published: Nov 1, 2018
Abstract
The ubiquitin proteasome system (UPS) is a complex cellular machinery that catalyzes degradation of misfolded or damaged proteins and regulates turnover of native proteins in eukaryotic cells, thus playing a crucial role in maintaining protein homeostasis. The UPS has emerged as a drug target for a diverse range of diseases characterized by accumulation of misfolded or aggregated proteins. While enhancement of UPS activity is widely recognized...
Paper Details
Title
A yeast selection system for the detection of proteasomal activation.
Published Date
Nov 1, 2018
Volume
31
Issue
11
Pages
437 - 445
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