The ion channel Piezo2 plays a role in early pain behaviors following DMM surgery in mice

Purpose: Osteoarthritis pain is often associated with mechanical stimuli, but the way that sensory neurons detect these painful stimuli remains unknown. The recently discovered mechanically sensitive ion channel, Piezo2, has been implicated in mediating proprioception and detecting light touch on the skin, as well as mechanical allodynia in a model of nerve injury. Those studies were performed by generating mice where Piezo2 was deleted on all...