Genome-wide analyses using UK biobank data povide new therapeutic targets for osteoarthritis

Purpose: Osteoarthritis (OA) is the most prevalent musculoskeletal disease and a leading cause of disability worldwide with huge public health burden. The pathogenesis of OA is complex with multiple environmental and genetic factors implicated in the disease aetiology and progression. The heritability of OA is ∼50% and previous genetic studies have identified 34 loci in total. Here, we conduct the largest genome-wide association study for OA to...