Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production
Abstract
Choline is a vitamin-like nutrient that is taken up via specific transporters and metabolized by choline kinase, which converts it to phosphocholine needed for de novo synthesis of phosphatidylcholine (PC), the main phospholipid of cellular membranes. We found that Toll-like receptor (TLR) activation enhances choline uptake by macrophages and microglia through induction of the choline transporter CTL1. Inhibition of CTL1 expression or choline...
Paper Details
Title
Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production
Published Date
Jun 1, 2019
Journal
Volume
29
Issue
6
Pages
1350 - 1362.e7
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