Match!

Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework.

Published on Jan 1, 2019in Progress in Brain Research2.961
· DOI :10.1016/bs.pbr.2019.03.012
Juyoen Hur5
Estimated H-index: 5
(UMD: University of Maryland, College Park),
Melissa D. Stockbridge1
Estimated H-index: 1
(Johns Hopkins University)
+ 1 AuthorsAlexander J. Shackman28
Estimated H-index: 28
(UMD: University of Maryland, College Park)
Abstract
Abstract When extreme, anxiety can become debilitating. Anxiety disorders, which often first emerge early in development, are common and challenging to treat, yet the underlying mechanisms have only recently begun to come into focus. Here, we review new insights into the nature and biological bases of dispositional negativity, a fundamental dimension of childhood temperament and adult personality and a prominent risk factor for the development of pediatric and adult anxiety disorders. Converging lines of epidemiological, neurobiological, and mechanistic evidence suggest that dispositional negativity increases the likelihood of psychopathology via specific neurocognitive mechanisms, including attentional biases to threat and deficits in executive control. Collectively, these observations provide an integrative translational framework for understanding the development and maintenance of anxiety disorders in adults and youth and set the stage for developing improved intervention strategies.
  • References (507)
  • Citations (3)
📖 Papers frequently viewed together
21 Citations
223 Citations
2013
9 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References507
Newest
#1Pinelopi Pliota (IMP: Research Institute of Molecular Pathology)H-Index: 3
#2Vincent Böhm (IMP: Research Institute of Molecular Pathology)H-Index: 2
Last. Wulf Haubensak (IMP: Research Institute of Molecular Pathology)H-Index: 13
view all 11 authors...
Survival relies on optimizing behavioral responses through experience. Animals often react to acute stress by switching to passive behavioral responses when coping with environmental challenge. Despite recent advances in dissecting mammalian circuitry for Pavlovian fear, the neuronal basis underlying this form of non-Pavlovian anxiety-related behavioral plasticity remains poorly understood. Here, we report that aversive experience recruits the posterior paraventricular thalamus (PVT) and cortico...
6 CitationsSource
#1Kenneth S. KendlerH-Index: 161
#2Charles O. GardnerH-Index: 34
Last. Nathan A. GillespieH-Index: 32
view all 10 authors...
4 CitationsSource
#1Vincent Taschereau-Dumouchel (UCLA: University of California, Los Angeles)H-Index: 4
#2Mitsuo KawatoH-Index: 72
Last. Hakwan LauH-Index: 36
view all 3 authors...
In studies of anxiety and other affective disorders, objectively measured physiological responses have commonly been used as a proxy for measuring subjective experiences associated with pathology. However, this commonly adopted “biosignal” approach has recently been called into question on the grounds that subjective experiences and objective physiological responses may dissociate. We performed machine-learning-based analyses on functional magnetic resonance imaging (fMRI) data to assess this is...
3 CitationsSource
#1Ashley L. Watts (MU: University of Missouri)H-Index: 11
#2Holly E. Poore (Emory University)H-Index: 3
Last. Irwin D. Waldman (Emory University)H-Index: 60
view all 3 authors...
We advanced several “riskier tests” of the validity of bifactor models of psychopathology, which included that the general and specific psychopathology factors should be reliable and well represent...
5 CitationsSource
#1Isabel Thielmann (University of Koblenz and Landau)H-Index: 11
#2Benjamin E. Hilbig (University of Koblenz and Landau)H-Index: 30
2 CitationsSource
#1Ziyan Luan (UU: Utrecht University)H-Index: 4
#2Astrid M. G. Poorthuis (UU: Utrecht University)H-Index: 6
Last. M.A.G. van Aken (UU: Utrecht University)H-Index: 42
view all 6 authors...
Objective What is gained by having others report on one’s personality? Research on adult samples has suggested that informant reports are especially informative regarding traits that are highly visible and evaluative (i.e., socially desirable/undesirable instead of neutral), such as Openness, Conscientiousness, and Agreeableness. This 18‐year longitudinal study aims to demonstrate the unique predictive power of other‐rated personality in adolescence, using life outcomes and personality in adulth...
4 CitationsSource
The Big Five personality traits have been linked to dozens of life outcomes. However, metascientific research has raised questions about the replicability of behavioral science. The Life Outcomes o...
3 CitationsSource
#1James J. Li (UW: University of Wisconsin-Madison)H-Index: 12
#2Emily C. Hilton (UW: University of Wisconsin-Madison)H-Index: 1
Last. Marsha R. Mailick (UW: University of Wisconsin-Madison)H-Index: 19
view all 6 authors...
2 CitationsSource
#1Amit LazarovH-Index: 9
Last. Yuval NeriaH-Index: 38
view all 7 authors...
3 CitationsSource
#1Michele Pignatelli (Picower Institute for Learning and Memory)H-Index: 13
#2Anna Beyeler (University of Bordeaux)H-Index: 10
The neural mechanisms underlying emotional valence are at the interface between perception and action, integrating inputs from the external environment with past experiences to guide the behavior of an organism. Depending on the positive or negative valence assigned to an environmental stimulus, the organism will approach or avoid the source of the stimulus. Multiple convergent studies have demonstrated that the amygdala complex is a critical node of the circuits assigning valence. Here we exami...
2 CitationsSource
Cited By3
Newest
#1Julie E. PremoH-Index: 4
#2Yanni LiuH-Index: 13
view all 6 authors...
In the following grant report, we describe initial and planned work supported by our National Institute of Mental Health R01-funded, Research Domain Criteria (RDoc) informed project, “Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety”. This project examines response to cognitive behavioral therapy (CBT) in a large sample of anxiety-affected and low-anxious youth ages 7 to 18 years using multiple levels of analysis, including brain imaging, behavioral performance, and cli...
1 CitationsSource
#1Juyoen Hur (Yonsei University)H-Index: 5
#1Juyoen Hur (Yonsei University)
Last. Alexander J. Shackman (UMD: University of Maryland, College Park)H-Index: 28
view all 10 authors...
When extreme, anxiety--a state of distress and arousal prototypically evoked by uncertain danger--can become debilitating. Uncertain anticipation is a shared feature of situations that elicit signs of anxiety across disorders, species, and assays. Despite the profound significance of anxiety for human health and wellbeing, the neurobiology of uncertain threat anticipation remains remarkably unsettled. Leveraging a paradigm adapted from animal research and optimized for functional MRI, we examine...
Source
#1Monika A. Waszczuk (SBU: Stony Brook University)H-Index: 12
#2Nicholas R. Eaton (SBU: Stony Brook University)H-Index: 28
Last. Roman Kotov (SBU: Stony Brook University)H-Index: 38
view all 33 authors...
Genetic discovery in psychiatry and clinical psychology is hindered by suboptimal phenotypic definitions. We argue that the hierarchical, dimensional, and data-driven classification system proposed by the Hierarchical Taxonomy of Psychopathology (HiTOP) consortium provides a more effective approach to identifying genes that underlie mental disorders, and to studying psychiatric etiology, than current diagnostic categories. Specifically, genes are expected to operate at different levels of the Hi...
6 CitationsSource
#1Lara Rösler (University of Würzburg)H-Index: 3
#2Matthias Gamer (University of Würzburg)H-Index: 6
Last. Matthias Gamer (University of Würzburg)H-Index: 30
view all 2 authors...
When confronted with threatening stimuli, animals typically respond with freezing behavior characterized by reduced movement and heart rate deceleration. Freezing-like responses during threat anticipation have also been observed in humans and are associated with anxiety. Recent evidence yet suggests that freezing does not necessarily reflect helpless immobility but can also aid the preparation of a threat escape. To investigate which further behavioral responses human freezing encompasses, we pr...
Source
#1Y. Stegmann (University of Würzburg)
#2Miriam A. Schiele (University of Freiburg)H-Index: 9
Last. Paul Pauli (University of Würzburg)H-Index: 50
view all 11 authors...
Previous research indicates that anxiety disorders are characterized by an overgeneralization of conditioned fear as compared with healthy participants. Therefore, fear generalization is considered a key mechanism for the development of anxiety disorders. However, systematic investigations on the variance in fear generalization are lacking. Therefore, the current study aims at identifying distinctive phenotypes of fear generalization among healthy participants. To this end, 1175 participants com...
Source
Source
#1Yannik Stegmann (University of Würzburg)
#2Philipp Reicherts (University of Würzburg)H-Index: 9
Last. Matthias J. Wieser (University of Würzburg)H-Index: 28
view all 5 authors...
Sensory processing and attention allocation are shaped by threat, but the role of trait-anxiety in sensory processing as a function of threat predictability remains incompletely understood. Therefore, we measured steady-state visual evoked potentials (ssVEPs) as an index of sensory processing of predictable and unpredictable threat cues in 29 low (LA) and 29 high (HA) trait-anxious participants during a modified NPU-paradigm followed by an extinction phase. Three different contextual cues indica...
Source