918 Skin morphogenesis by coupling biochemical-bioelectric signals: Calcium oscillations coordinate dermal cell movement by epidermis-derived SHH signaling during feather bud orientation

Tissue morphogenesis during development and wound healing may involve bio-electric mechanisms, but much is unknown. Using the developing chicken skin model, we found feather bud orientations, as a single bud and collectively as a population, are accompanied by dynamic changes of endogenous bioelectric current landscapes. Transcriptome profiling and functional assays implicate contributions from functional voltage-gated Ca2+ channels (VGCCs),...