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Published on Jan 1, 2018in Neuroscience Letters 2.17
Seyed Mojtaba Hosseini6
Estimated H-index: 6
(Shiraz University of Medical Sciences),
Mahsa Sani4
Estimated H-index: 4
(Shiraz University of Medical Sciences)
+ 4 AuthorsMohmmad Reza Namavar1
Estimated H-index: 1
(Shiraz University of Medical Sciences)
Abstract Treatment: with neural stem cells (NSCs) provides a hope to recover the neural damage and compensate for the lost neural structures for restoration of interrupted neural communications above and below the site of injury. However, cell-based therapy approach suffers from many biological barriers and technical caveats which severely hamper the prognosis. The biochemically-rich microenvironment at the site of spinal cord injury (SCI), the continuing neuro-degenerative process and infiltrat...
Published on Dec 1, 2017in The Journal of Spine Surgery
Ivan Cheng20
Estimated H-index: 20
,
Don Y. Park6
Estimated H-index: 6
+ 7 AuthorsAlexander I. Kharazi4
Estimated H-index: 4
Background: We previously reported that functional recovery of rats with spinal cord contusions can occur after acute transplantation of neural stem cells distal to the site of injury. To investigate the effects of timing of administration of human neural stem cell (hNSC) distal to the site of spinal cord injury on functional outcomes in an animal model. Methods: Thirty-six adult female Long-Evans hooded rats were randomized into three experimental and three control groups with six animals in ea...
Published on Sep 1, 2017in Neuroscience Letters 2.17
Zacnicte May5
Estimated H-index: 5
(U of A: University of Alberta),
Abel Torres-Espín10
Estimated H-index: 10
(U of A: University of Alberta)
+ 8 AuthorsJeff Biernaskie2
Estimated H-index: 2
(Alberta Children's Hospital)
Abstract A major goal of Schwann cell (SC) transplantation for spinal cord injury (SCI) is to fill the injury site to create a bridge for regenerating axons. However, transplantation of peripheral nerve SCs requires an invasive biopsy, which may result in nerve damage and donor site morbidity. SCs derived from multipotent stem cells found in skin dermis (SKP-SCs) are a promising alternative. Regardless of source, loss of grafted SCs post-grafting is an issue in studies of regeneration, with surv...
Published on May 15, 2017in Journal of Neurotrauma 3.75
CôtéMarie-Pascale1
Estimated H-index: 1
,
MurrayMarion1
Estimated H-index: 1
,
A LemayMichel1
Estimated H-index: 1
Abstract Body-weight supported locomotor training (BWST) promotes recovery of load-bearing stepping in lower mammals, but its efficacy in individuals with a spinal cord injury (SCI) is limited and highly dependent on injury severity. While animal models with complete spinal transections recover stepping with step-training, motor complete SCI individuals do not, despite similarly intensive training. In this review, we examine the significant differences between humans and animal models that may e...
Published on May 4, 2017in Expert Review of Neurotherapeutics 3.45
Michael A. Lane20
Estimated H-index: 20
(Drexel University),
Angelo C. Lepore25
Estimated H-index: 25
(Thomas Jefferson University),
Itzhak Fischer55
Estimated H-index: 55
(Drexel University)
ABSTRACTIntroduction: There have been a wide range of preclinical studies testing cellular therapies to repair the injured spinal cord, yet they remain a challenge to translate because of inconsistencies in efficacy, limited number of patients with acute/subacute SCI and the high costs of clinical trials.Area covered: This paper focusses on the therapeutic potential of neural precursor cells (NPCs) because they can provide the cellular components capable of promoting repair and enhancing functio...
Published on May 1, 2017in Nature Neuroscience 21.13
Peggy Assinck8
Estimated H-index: 8
,
Greg J. Duncan7
Estimated H-index: 7
+ 2 AuthorsWolfram Tetzlaff51
Estimated H-index: 51
The consequences of spinal cord injury are often severe and irreversible; cell transplantation has emerged as a potential treatment. In this Review, the authors highlight mechanisms through which cell transplantation is thought to promote functional improvements and the obstacles to making cell transplantation a viable therapy.
Published on Nov 1, 2016in Cell Stem Cell 21.46
Chiara Rolando9
Estimated H-index: 9
(University of Basel),
Andrea Erni2
Estimated H-index: 2
(University of Basel)
+ 7 AuthorsVerdon Taylor37
Estimated H-index: 37
(University of Basel)
Summary Adult neural stem cells (NSCs) are defined by their inherent capacity to self-renew and give rise to neurons, astrocytes, and oligodendrocytes. In vivo, however, hippocampal NSCs do not generate oligodendrocytes for reasons that have remained enigmatic. Here, we report that deletion of Drosha in adult dentate gyrus NSCs activates oligodendrogenesis and reduces neurogenesis at the expense of gliogenesis. We further find that Drosha directly targets NFIB to repress its expression independe...
Published on Aug 1, 2016in Tissue & Cell 1.55
Aikeremujiang Muheremu1
Estimated H-index: 1
(PRC: China Medical University (PRC)),
Jiang Peng3
Estimated H-index: 3
,
Qiang Ao3
Estimated H-index: 3
(PRC: China Medical University (PRC))
Treatment of spinal cord injury has always been a challenge for clinical practitioners and scientists. The development in stem cell based therapies has brought new hopes to patients with spinal cord injuries. In the last a few decades, a variety of stem cells have been used to treat spinal cord injury in animal experiments and some clinical trials. However, there are many technical and ethical challenges to overcome before this novel therapeutic method can be widely applied in clinical practice....
Published on Aug 1, 2016in Cell Transplantation 3.48
Xin-Yi Lin1
Estimated H-index: 1
(SYSU: Sun Yat-sen University),
Bi-Qin Lai7
Estimated H-index: 7
(SYSU: Sun Yat-sen University)
+ 4 AuthorsYuan-Shan Zeng21
Estimated H-index: 21
Spinal cord injury (SCI) can cause severe traumatic injury to the central nervous system (CNS). Current therapeutic effects achieved for SCI in clinical medicine show that there is still a long way to go to reach the desired goal of full or significant functional recovery. In basic medical research, however, cell transplantation, gene therapy, application of cytokines, and biomaterial scaffolds have been widely used and investigated as treatments for SCI. All of these strategies when used separa...
Published on May 15, 2016in Journal of Neurotrauma 3.75
Elena Redondo-Castro7
Estimated H-index: 7
,
Xavier Navarro59
Estimated H-index: 59
,
Guillermo García-Alías15
Estimated H-index: 15
Abstract We have applied transcranial electrical stimulation to rats with spinal cord injury and selectively tested the motor evoked potentials (MEPs) conveyed by descending motor pathways with cortical and subcortical origin. MEPs were elicited by electrical stimulation to the brain and recorded on the tibialis anterior muscles. Stimulation parameters were characterized and changes in MEP responses tested in uninjured rats, in rats with mild or moderate contusion, and in animals with complete t...
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