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TGF-β-induced long non-coding RNA MIR155HG promotes the progression and EMT of laryngeal squamous cell carcinoma by regulating the miR-155-5p/SOX10 axis

Published on Apr 12, 2019in International Journal of Oncology3.571
· DOI :10.3892/ijo.2019.4784
Weina Cui2
Estimated H-index: 2
(Hebei Medical University),
Wenxia Meng2
Estimated H-index: 2
(Hebei Medical University)
+ 3 AuthorsBaoshan Wang4
Estimated H-index: 4
(Hebei Medical University)
Abstract
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  • Citations (2)
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Abstract No longer regarded as junk DNA, long non-coding RNAs (lncRNAs) are considered as master regulators of cancer development and metastasis nowadays. Among the recently appreciated roles of these transcripts is their fundamental contribution in the pathogenesis of head and neck squamous cell carcinoma (HNSCC). Notably, lncRNAs may have interactions with some environmental risk factors for this type of cancer. Moreover, a number of studies have verified diagnostic and prognostic values of ln...
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ABSTRACTNumerous findings have demonstrated that MicroRNAs dysregulation plays a key role in many neoplasms, including oral squamous cell carcinoma (OSCC), yet the potential mechanisms of microRNAs...
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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common human malignancy in the world, with high mortality and poor prognosis for patients. Among the risk factors are tobacco and alcohol intake, human papilloma virus, and also genetic and epigenetic modifications. Many studies show that epigenetic events play an important role in HNSCC development and progression, including DNA methylation, chromatin remodeling, histone posttranslational covalent modifications, and effects of non-...
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Abstract Long non-coding RNA RGMB-AS1 (lncRNA RGMB-AS1) was reported to play important roles in human cancer progression. However, the roles of lncRNA RGMB-AS1 in laryngeal squamous cell carcinoma (LSCC) remain unclear. In our research, lncRNA RGMB-AS1 was shown to be upregulated in LSCC tissues. High RGMB-AS1 expression was closely associated with advanced clinical features and poor prognosis. Silencing of lncRNA RGMB-AS1 suppressed LSCC cells proliferation and invasion in vitro and inhibited t...
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In recent years, immune checkpoint inhibitor has achieved remarkable success in multiple cancer treatment. However, how to pre‐judge which patients are suitable for immune checkpoint inhibitor is a difficult problem. We use the existing public bioinformatics database to comprehensively analyze the relationship between clinical data of various cancers with immune checkpoint blocking molecules and long non‐coding RNAs (lncRNAs), and try to find the potential predictive value of lncRNA for immunoth...
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