Islet inflammation in type 2 diabetes

Published on Apr 15, 2019in Seminars in Immunopathology6.80
· DOI :10.1007/s00281-019-00745-4
Marianne Böni-Schnetzler21
Estimated H-index: 21
(University Hospital of Basel),
Daniel T. Meier (University Hospital of Basel)
Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell failure is a major component of the pathogenesis of type 2 diabetes. It is now well established that increased numbers of innate immune cells, cytokines, and chemokines have detrimental effects on islets in these chronic conditions. Recently, evidence emerged which points to initially adaptive and restorative functions of inflammatory factors and immune cells in metabolism. In the following review, we provide an overview on the features of islet inflammation in diabetes and models of prediabetes. We separately emphasize what is known on islet inflammation in humans and focus on in vivo animal models and how they are used to elucidate mechanistic aspects of islet inflammation. Further, we discuss the recently emerging physiologic signaling role of cytokines during adaptation and normal function of islet cells.
  • References (108)
  • Citations (1)
#1Wei Ying (UCSD: University of California, San Diego)H-Index: 12
#2Yun Sok Lee (UCSD: University of California, San Diego)H-Index: 27
Last.Matthew Riopel (UCSD: University of California, San Diego)H-Index: 3
view all 10 authors...
#1Anping Song (HUST: Huazhong University of Science and Technology)H-Index: 1
#2L. Zhu (Sichuan University)H-Index: 3
Last.Ning Quan (OSU: Ohio State University)H-Index: 31
view all 10 authors...
#1Jonathan Weitz (UM: University of Miami)H-Index: 5
#2Madina Makhmutova (UM: University of Miami)H-Index: 3
Last.Alejandro Caicedo (UM: University of Miami)H-Index: 30
view all 9 authors...
#1Thierry M. Nordmann (University of Basel)H-Index: 3
#2Erez Dror (University of Basel)H-Index: 7
Last.Marc Y. Donath (University of Basel)H-Index: 57
view all 8 authors...
View next paperIslet inflammation in type 2 diabetes and physiology