Effects of prolonged chemogenetic inhibition of nociceptors in a murine surgical model of osteoarthritis

Purpose: The aim of this study was to explore the effects of prolonged chemogenetic inhibition of nociceptors on pain-related behaviors, cellular changes in the dorsal root ganglia (DRG), as well as on joint damage in a murine model of knee osteoarthritis (OA). After destabilization of the medial meniscus (DMM), mice develop pain-related behaviors in association with progressive joint damage, including knee hyperalgesia and mechanical allodynia...