343 Glucocorticoids interfere with skin barrier function through the activation of mineralocorticoid receptor as well as glucocorticoid receptor

Exogenous or endogenous glucocorticoids (GC) have negative effects on skin barrier function as well as wound healing. In skin where 11β-hydroxysteroid dehydrogenase 2 which prevents GC from binding to mineralocorticoid receptor (MR) is deficient, GC can bind to MR as well as GC receptor (GR). MR has been known to be implicated in GC-induced delayed wound healing and epidermal atrophy. We performed this study whether GC binds to MR and...