Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits
Abstract
Genetic correlations estimated from genome-wide association studies (GWASs) reveal pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural equation modelling (genomic SEM): a multivariate method for analysing the joint genetic architecture of complex traits. Genomic SEM synthesizes genetic correlations and single-nucleotide polymorphism heritabilities inferred from GWAS summary statistics of individual traits...
Paper Details
Title
Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits
Published Date
Apr 8, 2019
Journal
Volume
3
Issue
5
Pages
513 - 525
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