Identification of the gene cluster for bistropolone-humulene meroterpenoid biosynthesis in Phoma sp.
Abstract
Eupenifeldin, a bistropolone meroterpenoid, was first discovered as an antitumor agent from the fungus Eupenicillium brefeldianum. We also isolated this compound and a new congener from a strain of Phoma sp. (CGMCC 10481), and evaluated their antitumor effects. Eupenifeldin showed potent in vitro anti-glioma activity. This tropolone-humulene-tropolone meroterpenoid could be originated from two units of tropolone orthoquinone methides and a...
Paper Details
Title
Identification of the gene cluster for bistropolone-humulene meroterpenoid biosynthesis in Phoma sp.
Published Date
Aug 1, 2019
Journal
Volume
129
Pages
7 - 15
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Notes
History