Hepatic Insulin Clearance: Mechanism and Physiology
Abstract
Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal circulation to exert its action and eventually undergo clearance in the hepatocytes. In addition to insulin secretion, hepatic insulin clearance regulates the homeostatic level of insulin that is required to reach peripheral insulin target tissues to elicit proper insulin action. Receptor-mediated insulin uptake followed by its degradation constitutes the...
Paper Details
Title
Hepatic Insulin Clearance: Mechanism and Physiology
Published Date
May 1, 2019
Journal
Volume
34
Issue
3
Pages
198 - 215
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