Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms

Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome-wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the genetic determinants of PD age at onset are largely unknown.To identify the genetic determinants of PD age at onset.Using genetic data of 28,568 PD cases, we performed a genome-wide association study based on PD age at onset.We estimated that...