Growth Hormone Induces Colon DNA Damage Independent of IGF-1
Abstract
DNA damage occurs as a result of environmental insults and aging and, if unrepaired, may lead to chromosomal instability and tumorigenesis. Because GH suppresses ataxia-telangiectasia mutated kinase phosphorylation, decreases DNA repair, and increases DNA damage accumulation, we elucidated whether GH effects on DNA damage are mediated through induced IGF-1. In nontumorous human colon cells, GH, but not IGF-1, increased DNA damage. Stably...
Paper Details
Title
Growth Hormone Induces Colon DNA Damage Independent of IGF-1
Published Date
Apr 19, 2019
Journal
Volume
160
Issue
6
Pages
1439 - 1447
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