New developments in the diagnosis of fibrillary glomerulonephritis

Fibrillary glomerulonephritis is a glomerular disease historically defined by glomerular deposition of Congo red–negative, randomly oriented straight fibrils that lack a hollow center and stain with antisera to immunoglobulins. It was initially considered to be an idiopathic disease, but recent studies highlighted association in some cases with autoimmune disease, malignant neoplasm, or hepatitis C viral infection. Prognosis is poor with nearly...