Match!

Sitting Time, Physical Activity, and Risk of Mortality in Adults

Published on Apr 1, 2019in Journal of the American College of Cardiology18.639
· DOI :10.1016/j.jacc.2019.02.031
Emmanuel Stamatakis64
Estimated H-index: 64
(USYD: University of Sydney),
Joanne Gale8
Estimated H-index: 8
(USYD: University of Sydney)
+ 3 AuthorsDing Ding26
Estimated H-index: 26
(USYD: University of Sydney)
Sources
Abstract
Abstract Background It is unclear what level of moderate to vigorous intensity physical activity (MVPA) offsets the health risks of sitting. Objectives The purpose of this study was to examine the joint and stratified associations of sitting and MVPA with all-cause and cardiovascular disease (CVD) mortality, and to estimate the theoretical effect of replacing sitting time with physical activity, standing, and sleep. Methods A longitudinal analysis of the 45 and Up Study calculated the multivariable-adjusted hazard ratios (HRs) of sitting for each sitting-MVPA combination group and within MVPA strata. Isotemporal substitution modeling estimated the per-hour HR effects of replacing sitting. Results A total of 8,689 deaths (1,644 due to CVD) occurred among 149,077 participants over an 8.9-year (median) follow-up. There was a statistically significant interaction between sitting and MVPA only for all-cause mortality. Sitting time was associated with both mortality outcomes in a nearly dose-response manner in the least active groups reporting  8 h/day) to the least sedentary ( 6 sitting h/day) where, for example, the per-hour CVD mortality HR for sitting replaced with vigorous activity was 0.36 (95% confidence interval: 0.17 to 0.74). Conclusions Sitting is associated with all-cause and CVD mortality risk among the least physically active adults; moderate-to-vigorous physical activity doses equivalent to meeting the current recommendations attenuate or effectively eliminate such associations.
Figures & Tables
  • References (32)
  • Citations (11)
📖 Papers frequently viewed together
2019
6 Authors (Emmanuel Stamatakis, ..., Ding Ding)
1 Citations
1 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References32
Newest
#1Ulf EkelundH-Index: 86
#2Wendy J. Brown (UQ: University of Queensland)H-Index: 68
Last. I-Min LeeH-Index: 98
view all 8 authors...
Objective To examine whether the associations between sedentary behaviours (ie, daily sitting/TV-viewing time) and mortality from cardiovascular disease (CVD) and cancer differ by different levels of physical activity (PA). Design Harmonised meta-analysis of prospective cohort studies. Data on exposure variables were harmonised according to a predefined protocol and categorised into four groups for sedentary behaviours and into quartiles of PA (MET-hour/week). Data sources PubMed, PsycINFO, Emba...
18 CitationsSource
#2Marieke De Craemer (UGent: Ghent University)H-Index: 19
Last. Emmanuel Stamatakis (USYD: University of Sydney)H-Index: 64
view all 8 authors...
Aim To assess the relationship between time spent in light physical activity and cardiometabolic health and mortality in adults. Design Systematic review and meta-analysis. Data sources Searches in Medline, Embase, PsycInfo, CINAHL and three rounds of hand searches. Eligibility criteria for selecting studies Experimental (including acute mechanistic studies and physical activity intervention programme) and observational studies (excluding case and case–control studies) conducted in adults (aged ...
25 CitationsSource
#1Emmanuel Stamatakis (USYD: University of Sydney)H-Index: 64
#2Ulf Ekelund (Norwegian School of Sport Sciences)H-Index: 86
Last. I-Min LeeH-Index: 98
view all 6 authors...
Sedentary behaviour (SB) has been proposed as an ‘independent’ risk factor for chronic disease risk, attracting much research and media attention. Many countries have included generic, non-quantitative reductions in SB in their public health guidelines and calls for quantitative SB targets are increasing. The aim of this narrative review is to critically evaluate key evidence areas relating to the development of guidance on sitting for adults. We carried out a non-systematic narrative evidence s...
19 CitationsSource
#1Katrina L. Piercy (HHS: United States Department of Health and Human Services)H-Index: 3
#2Richard P. Troiano (HHS: United States Department of Health and Human Services)H-Index: 2
Last. Richard D. Olson (HHS: United States Department of Health and Human Services)H-Index: 2
view all 8 authors...
Importance Approximately 80% of US adults and adolescents are insufficiently active. Physical activity fosters normal growth and development and can make people feel, function, and sleep better and reduce risk of many chronic diseases. Objective To summarize key guidelines in the Physical Activity Guidelines for Americans , 2nd edition (PAG). Process and Evidence Synthesis The 2018 Physical Activity Guidelines Advisory Committee conducted a systematic review of the science supporting physical ac...
181 CitationsSource
#1Richard Patterson (Imperial College London)H-Index: 2
#2Eoin McNamara (University of Cambridge)H-Index: 1
Last. Katrien Wijndaele (University of Cambridge)H-Index: 36
view all 10 authors...
Purpose: To estimate the strength and shape of the dose–response relationship between sedentary behaviour and all-cause, cardiovascular disease (CVD) and cancer mortality, and incident type 2 diabetes (T2D), adjusted for physical activity (PA). Data Sources: Pubmed, Web of Knowledge, Medline, Embase, Cochrane Library and Google Scholar (through September-2016); reference lists. Study Selection: Prospective studies reporting associations between total daily sedentary time or TV viewing time, and ...
62 CitationsSource
There are discrepant findings between (A) observational follow-ups and (B) interventional studies that investigate possible causal association between high physical activity and low mortality. Participation in vigorous physical activity at a specific time-point is an indicator of good fitness and health, and is associated with a reduced risk of death. However, neither randomised controlled trials nor experimental animal studies have provided conclusive evidence to show that physical activity sta...
11 CitationsSource
#1Stephanie A. Prince (U of O: University of Ottawa)H-Index: 12
#2G LeBlancAllana (U of O: University of Ottawa)H-Index: 24
Last. Travis J. Saunders (UPEI: University of Prince Edward Island)H-Index: 24
view all 4 authors...
17 CitationsSource
#1Deborah Rohm Young (WLAC: West Los Angeles College)H-Index: 1
#2Marie-France Hivert (Harvard University)H-Index: 38
Last. Celina M. Yong (Stanford University)H-Index: 10
view all 11 authors...
Epidemiological evidence is accumulating that indicates greater time spent in sedentary behavior is associated with all-cause and cardiovascular morbidity and mortality in adults such that some countries have disseminated broad guidelines that recommend minimizing sedentary behaviors. Research examining the possible deleterious consequences of excess sedentary behavior is rapidly evolving, with the epidemiology-based literature ahead of potential biological mechanisms that might explain the obse...
138 CitationsSource
#1Ulf Ekelund (Norwegian School of Sport Sciences)H-Index: 86
#2Jostein Steene-Johannessen (Norwegian School of Sport Sciences)H-Index: 22
Last. I-Min Lee (Harvard University)H-Index: 98
view all 8 authors...
Summary Background High amounts of sedentary behaviour have been associated with increased risks of several chronic conditions and mortality. However, it is unclear whether physical activity attenuates or even eliminates the detrimental effects of prolonged sitting. We examined the associations of sedentary behaviour and physical activity with all-cause mortality. Methods We did a systematic review, searching six databases (PubMed, PsycINFO, Embase, Web of Science, Sport Discus, and Scopus) from...
576 CitationsSource
#1Ambarish Pandey (UTSW: University of Texas Southwestern Medical Center)H-Index: 29
#2Usman Salahuddin (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
Last. Jarett D. Berry (UTSW: University of Texas Southwestern Medical Center)H-Index: 22
view all 10 authors...
Importance Prior studies suggest that higher sedentary time is associated with a greater risk for cardiovascular disease (CVD). However, the quantitative, dose-response association between sedentary time and CVD risk is not known. Objective To determine the categorical and quantitative dose-response association between sedentary time and CVD risk. Data Sources Two independent investigators searched the MEDLINE and EMBASE databases for all studies published before July 6, 2015, that evaluated the...
36 CitationsSource
Cited By11
Newest
Source
#2Christer MalmH-Index: 18
Last. Michael SvenssonH-Index: 15
view all 5 authors...
Source
#1Nicole E. Blackburn (RMIT: RMIT University)H-Index: 2
#2Jason J. Wilson (RMIT: RMIT University)H-Index: 2
Last. Manuela Deidda (Glas.: University of Glasgow)H-Index: 8
view all 13 authors...
BACKGROUND: Evidence suggests that sedentary behaviour (SB) is associated with poor health outcomes. SB at any age may have significant consequences for health and well-being and interventions targeting SB are accumulating. Therefore, the need to review the effects of multicomponent, complex interventions that incorporate effective strategies to reduce SB are essential. METHODS: A systematic review and meta-analysis were conducted investigating the impact of interventions targeting SB across the...
Source
#1Leanne Hassett (RMIT: RMIT University)
#2Louise Ada (RMIT: RMIT University)
Last. Catherine M. Dean (Macquarie University)H-Index: 31
view all 6 authors...
BACKGROUND AND PURPOSE: Understanding how both active and sedentary time is accumulated in people after stroke may help to better target interventions to reduce stroke recurrence. This study aimed to determine the difference between stroke and healthy controls in (a) time spent in sedentary and active behaviour, (b) frequency of short and long active and sedentary bouts and (c) time spent in short and long active and sedentary bouts. METHODS: Analysis of secondary outcomes from a cross-sectional...
Source
#1Mireia Felez-Nobrega (UVic-UCC: University of Vic)H-Index: 2
#2Judit Bort-Roig (UVic-UCC: University of Vic)H-Index: 5
Last. Anna Puig-Ribera (UVic-UCC: University of Vic)H-Index: 12
view all 7 authors...
This study examined relationships between physical activity (PA) and sedentary behaviour (SB) with state-trait anxiety and stress. State-Trait anxiety (State-Trait Anxiety Inventory), psychological stress (Perceived Stress Scale), SB across domains during weekdays and weekends (Last 7-day Sedentary Behaviour Questionnaire) and PA intensities (International Physical Activity Questionnaire) were assessed by self-report in 360 undergraduates (44% females, mean age 20.9 +/- 2.93 years). A subsample ...
Source
#1Sonia W.M. Cheng (USYD: University of Sydney)H-Index: 1
#2Jennifer A. Alison (USYD: University of Sydney)H-Index: 28
Last. Zoe J. McKeough (USYD: University of Sydney)H-Index: 17
view all 5 authors...
Few studies have used 24-hour accelerometery to characterise posture and movement patterns in people with chronic obstructive pulmonary disease (COPD). This study aimed to quantify sedentary behaviour (SB), patterns of SB accumulation and physical activity (PA) in people with COPD, and to examine physiological and functional capacity correlates of total SB and patterns of SB accumulation. SB and PA were assessed continuously over seven days using thigh-worn accelerometery in people with COPD. Pa...
Source
#1David A. Raichlen (SC: University of Southern California)H-Index: 29
#1David A. Raichlen (SC: University of Southern California)
Last. Brian M. Wood (MPG: Max Planck Society)H-Index: 17
view all 7 authors...
Recent work suggests human physiology is not well adapted to prolonged periods of inactivity, with time spent sitting increasing cardiovascular disease and mortality risk. Health risks from sitting are generally linked with reduced levels of muscle contractions in chair-sitting postures and associated reductions in muscle metabolism. These inactivity-associated health risks are somewhat paradoxical, since evolutionary pressures tend to favor energy-minimizing strategies, including rest. Here, we...
2 CitationsSource
Each week, I record audio summaries for every paper in JACC, as well as an issue summary. Although this process is quite time-consuming, I have become familiar with every paper that we publish. Thus, I have personally selected the top 100 papers (both Original Investigations and Review Articles, and an occasional Editorial Comment) from the distinct specialties each year. In addition to my personal choices, I have included papers that have been the most accessed or downloaded on our websites, as...
Source
#1Carlijn M. Maasakkers (Radboud University Nijmegen)H-Index: 1
#2Rianne A.A. de Heus (Radboud University Nijmegen)H-Index: 1
Last. Jurgen A.H.R. Claassen (Radboud University Nijmegen)H-Index: 31
view all 6 authors...
BACKGROUND: Physicians are cautious to prescribe antihypertensive drugs in frail older adults because of the potential adverse effects, especially in those with cognitive complaints. Lifestyle aspects might provide safe targets to lower blood pressure in older adults. OBJECTIVE: Our goal was to evaluate the associations between activity patterns and blood pressure in memory clinic patients. METHODS: We used an observational cross-sectional study to measure activity patterns with the ActivPAL acc...
Source
#1Shuo Li (SUS: Shanghai University of Sport)
#2Jingjing Xue (Beijing Dance Academy)
Last. Zihong He
view all 5 authors...
The purpose of this study was to compare differences of energy expenditure and substrate metabolism between motorized-treadmill and overground running in three different velocities in Chinese middle-aged women. In total, 74 healthy middle-aged women (age, 48 ± 4 years; height, 159.4 ± 4.9 cm; weight, 58.6 ± 6.7 kg; and body-mass index (BMI), 23.1 ± 2.7 kg/m2) volunteered to participate in this study. Bioelectrical-impedance analysis was used to measure body composition. Energy expenditure, carbo...
Source