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Genetic Determinants of Weight Loss After Bariatric Surgery

Published on Apr 17, 2019in Obesity Surgery 3.60
· DOI :10.1007/s11695-019-03878-5
Martin Aasbrenn (Innlandet Hospital Trust), Theresia M. Schnurr3
Estimated H-index: 3
(UCPH: University of Copenhagen)
+ 13 AuthorsTorben Hansen85
Estimated H-index: 85
(UCPH: University of Copenhagen)
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Abstract
Background The weight loss after bariatric surgery shows considerable individual variation. Twin studies of response to dietary interventions and studies of bariatric surgery patients suggest that genetic differences may play a role. This study aimed to examine the effect of three genetic risk scores on the inter-individual variation in excess body mass index loss (EBMIL) after Roux-en-Y gastric bypass. Furthermore, we searched among known adiposity-related single nucleotide polymorphisms (SNPs) for genetic determinants of the inter-individual variation in EBMIL.
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References25
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Published on Sep 6, 2018in JCI insight
Juan de Toro-Martín2
Estimated H-index: 2
,
Frédéric Guénard13
Estimated H-index: 13
+ 3 AuthorsMarie-Claude Vohl44
Estimated H-index: 44
Published on Jun 1, 2018in Current Opinion in Genetics & Development 5.29
Ruth J. F. Loos108
Estimated H-index: 108
(ISMMS: Icahn School of Medicine at Mount Sinai)
Genome-wide discovery efforts have identified more than 500 genetic loci associated with adiposity traits. The vast majority of these loci were found through large-scale meta-analyses for body mass index (BMI) and waist-to-hip ratio (WHR), and in European ancestry populations. However, alternative approaches, focusing on non-European ancestry populations, more refined adiposity measures, and low-frequency (minor allele frequency (MAF)
Published on Jan 16, 2018in JAMA 51.27
Ralph Peterli24
Estimated H-index: 24
,
Bettina K. Wölnerhanssen14
Estimated H-index: 14
+ 9 AuthorsMarc Schiesser21
Estimated H-index: 21
Importance Sleeve gastrectomy is increasingly used in the treatment of morbid obesity, but its long-term outcome vs the standard Roux-en-Y gastric bypass procedure is unknown. Objective To determine whether there are differences between sleeve gastrectomy and Roux-en-Y gastric bypass in terms of weight loss, changes in comorbidities, increase in quality of life, and adverse events. Design, Setting, and Participants The Swiss Multicenter Bypass or Sleeve Study (SM-BOSS), a 2-group randomized tria...
Published on Jan 16, 2018in JAMA 51.27
Ralph Peterli24
Estimated H-index: 24
,
Bettina K. Wölnerhanssen14
Estimated H-index: 14
(University Hospital of Basel)
+ 9 AuthorsMarc Schiesser2
Estimated H-index: 2
(Kantonsspital St. Gallen)
Importance Sleeve gastrectomy is increasingly used in the treatment of morbid obesity, but its long-term outcome vs the standard Roux-en-Y gastric bypass procedure is unknown. Objective To determine whether there are differences between sleeve gastrectomy and Roux-en-Y gastric bypass in terms of weight loss, changes in comorbidities, increase in quality of life, and adverse events. Design, Setting, and Participants The Swiss Multicenter Bypass or Sleeve Study (SM-BOSS), a 2-group randomized tria...
Published on Feb 1, 2017in Surgical Laparoscopy Endoscopy & Percutaneous Techniques 1.34
Emma Osland11
Estimated H-index: 11
,
Rossita M. Yunus11
Estimated H-index: 11
+ 2 AuthorsMuhammed Ashraf Memon30
Estimated H-index: 30
Purpose: Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic vertical sleeve gastrectomy (LVSG), have been proposed as cost effective strategies to manage morbid obesity. This aim of this meta-analysis was to compared the postoperative weight loss outcomes reported in randomised control trials (RCTs) for LVSG versus LRYGB procedures. Material and Methods: RCTs comparing the weight loss outcomes following LVSG and LRYGB in adult population between January 2000 and November 2015 were se...
Published on Dec 1, 2016in BMC Endocrine Disorders 1.82
Mogens Fenger32
Estimated H-index: 32
,
Dorte Hansen10
Estimated H-index: 10
+ 4 AuthorsSten Madsbad63
Estimated H-index: 63
Background Roux-en-Y gastric bypass surgery is widely applied to ameliorate morbid obesity, including diabetes in people with type 2 diabetes. The latter vanish a few days after surgery for many, but not in all patients before any weight reduction has occurred. The explanation for this change in metabolic status is poorly understood, but the observation may suggest that the fate obesity and diabetes is only partly linked after surgery.
Published on Sep 20, 2016in BMJ 27.60
Katherine M. Livingstone16
Estimated H-index: 16
(Newcastle University),
Carlos Celis-Morales19
Estimated H-index: 19
(Glas.: University of Glasgow)
+ 29 AuthorsTao Huang19
Estimated H-index: 19
(Tulane University)
Objective To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials. Design Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials. Data sources Ovid Medline, Scopus, Embase, and Cochrane from inception to November 2015. Eligibility criteria for study selection Randomised controlled trials in overweight or obese adults reporting reduction in bod...
Published on Sep 1, 2016in Obesity Surgery 3.60
Marcus Bandstein6
Estimated H-index: 6
(Uppsala University),
Sarah Voisin9
Estimated H-index: 9
(Uppsala University)
+ 6 AuthorsHelgi B. Schiöth70
Estimated H-index: 70
(Uppsala University)
Background Currently, Roux-en Y gastric bypass (RYGB) is the most efficient therapy for severe obesity. Weight loss after surgery is, however, highly variable and genetically influenced. Genome-wide association studies have identified several single nucleotide polymorphisms (SNP) associated with body mass index (BMI) and waist-hip ratio (WHR). We aimed to identify two genetic risk scores (GRS) composed of weighted BMI and WHR-associated SNPs to estimate their impact on excess BMI loss (EBMIL) af...
Published on Sep 1, 2016in Scandinavian Journal of Gastroenterology 2.15
Marcus Bandstein6
Estimated H-index: 6
(Uppsala University),
Jessica Mwinyi9
Estimated H-index: 9
(Uppsala University)
+ 3 AuthorsHelgi B. Schiöth70
Estimated H-index: 70
(Uppsala University)
AbstractObjective: Bariatric surgery is the most efficient treatment of severe obesity. We investigated to what extent BMI- or waist-hip ratio (WHR)-related genetic variants are associated with excess BMI loss (EBMIL) two years after Roux-en-Y gastric bypass (RYGB) surgery, and elucidated the affected biological pathways.Methods: Two-hundred fifty-one obese patients (age: 43 ± 10.7, preoperative BMI: 45.1 ± 6.1 kg/m2, 186 women) underwent RYGB surgery and were followed up after two years with re...
Published on Aug 1, 2015in Obesity Surgery 3.60
Oleg Borisenko3
Estimated H-index: 3
,
Zeynep Colpan2
Estimated H-index: 2
+ 3 AuthorsAhmed R. Ahmed19
Estimated H-index: 19
(Imperial College London)
Purpose The objective of this study was to evaluate the current utilization, the level of endorsement by professional societies, and health technology assessment bodies, as well as the reimbursement levels for bariatric surgery in European countries. Materials and Methods We performed an analysis of the indications for bariatric surgery based on national clinical and commissioning guidelines, current utilization of surgery, characteristics of patients who underwent surgery, and reimbursement tar...
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