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Ten-Year Legacy Effects of Three Eight-Month Exercise Training Programs on Cardiometabolic Health Parameters

Published on Apr 16, 2019in Frontiers in Physiology3.201
· DOI :10.3389/fphys.2019.00452
Johanna L. Johnson14
Estimated H-index: 14
(Duke University),
Cris A. Slentz36
Estimated H-index: 36
(Duke University)
+ 2 AuthorsWilliam E. Kraus79
Estimated H-index: 79
(Duke University)
Abstract
Background: STRRIDE (Studies Targeting Risk Reduction Interventions through Defined Exercise) was an eight-month exercise study conducted from 1998-2003. Subjects were randomized to control or one of three exercise groups differing in intensity and amount. To determine if there were legacy effects, we invited 161 individuals who completed the intervention phase to return for a 10-year Reunion study. Methods: Subjects completed medical history and physical activity questionnaires. Height, body weight, blood pressure, waist circumference, and peak VO2 were measured. Fasting blood samples were analyzed for glucose, insulin and lipids. Of 161 original subjects, 153 were within 10 years of STRRIDE completion. Of these, 28 were lost to follow-up and 21 declined to participate in the Reunion study. Overall, 104 subjects (83% eligible) participated. Change over time was computed as the 10-year reunion value minus the pre-intervention value. Significant within group changes were calculated using two-tailed t-tests. ANCOVA determined differences among groups with pre-intervention values as covariates. Bonferroni corrections were applied to account for multiple comparisons. Results: Ten years after completing STRRIDE, there were a number of group-specific health and fitness legacy effects. Original participation in either the moderate intensity exercise or control group resulted in a 10.5% decrease in peak VO2 over the ensuing 10 years. Conversely, both vigorous intensity groups experienced only a 4.7% decrement in cardiorespiratory fitness over that time period. As compared to controls, all three exercise groups experienced smaller increases in waist circumference. Those who participated in moderate intensity exercise experienced the greatest 10-year reduction in fasting insulin. Compared to all other groups, the moderate intensity subjects had greater reductions in mean arterial pressure at the Reunion timepoint. Summary: Ten years after completing a randomized eight-month exercise training intervention, previously sedentary individuals exhibited group-specific differences consistent with an intervention-based legacy effect on cardiorespiratory fitness and cardiometabolic parameters. These findings highlight the critical need to better understand the sustained legacy health effects of exercise training interventions.
  • References (24)
  • Citations (3)
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References24
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The West of Scotland Coronary Prevention Study (WOSCOPS) was a randomized, placebo- controlled, primary prevention trial of pravastatin in men aged 45 to 64 (mean age of 55 years) with no history of myocardial infarction at randomization. A total of 6,595 men, with a mean (SD) plasma cholesterol level of 272 (23) mg/dL and mean (SD) low density lipoprotein cholesterol (LDL-C) of 192 (17) mg/dL were randomly assigned to receive pravastatin 40 mg daily or placebo for five years. The primary outcom...
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#1Jessica L. Unick (Brown University)H-Index: 15
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#1Cris A. Slentz (Duke University)H-Index: 36
#2Lori A. Bateman (Duke University)H-Index: 14
Last. William E. Kraus (Duke University)H-Index: 79
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#1Peter S. Sever (Imperial College London)H-Index: 70
#2Choon L. Chang (Imperial College London)H-Index: 11
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Regular physical activity significantly affects lipid status. In this literature review, the specific features of athletes blood lipid profiles were analysed. Professional athletes blood lipid status was found considerably preferable compared to sex- and age-matched sedentary population. Regardless of endurance or power type of sports activities, athletes perform lower levels of TC, LDL-C and TG and comparable or higher blood levels of HDL-C. The differences in blood lipids levels and sports dis...
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Regular physical exercise is the most efficient and accessible intervention known to promote healthy aging in humans. The molecular and cellular mechanisms that mediate system-wide exercise benefits, however, remain poorly understood, especially as applies to tissues that do not participate directly in training activity. The establishment of exercise protocols for short-lived genetic models will be critical for deciphering fundamental mechanisms of transtissue exercise benefits to healthy aging....
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#1Samuel Dagogo-Jack (UTHSC: University of Tennessee Health Science Center)H-Index: 38
Lifestyle interventions in patients with prediabetes can delay the onset of type 2 diabetes mellitus, but long-term data on diabetes complications are lacking. A new report from the Da Qing Study provides data on the effect of lifestyle interventions on diabetes mellitus complications and mortality in patients with prediabetes who were followed up for 30 years.
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#1Ricardo Laranjeiro (RU: Rutgers University)H-Index: 4
#2Girish Harinath (RU: Rutgers University)H-Index: 3
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