Ten-Year Legacy Effects of Three Eight-Month Exercise Training Programs on Cardiometabolic Health Parameters

Published on Apr 16, 2019in Frontiers in Physiology3.20
· DOI :10.3389/fphys.2019.00452
Johanna L. Johnson14
Estimated H-index: 14
(Duke University),
Cris A. Slentz35
Estimated H-index: 35
(Duke University)
+ 2 AuthorsWilliam E. Kraus76
Estimated H-index: 76
(Duke University)
Background: STRRIDE (Studies Targeting Risk Reduction Interventions through Defined Exercise) was an eight-month exercise study conducted from 1998-2003. Subjects were randomized to control or one of three exercise groups differing in intensity and amount. To determine if there were legacy effects, we invited 161 individuals who completed the intervention phase to return for a 10-year Reunion study. Methods: Subjects completed medical history and physical activity questionnaires. Height, body weight, blood pressure, waist circumference, and peak VO2 were measured. Fasting blood samples were analyzed for glucose, insulin and lipids. Of 161 original subjects, 153 were within 10 years of STRRIDE completion. Of these, 28 were lost to follow-up and 21 declined to participate in the Reunion study. Overall, 104 subjects (83% eligible) participated. Change over time was computed as the 10-year reunion value minus the pre-intervention value. Significant within group changes were calculated using two-tailed t-tests. ANCOVA determined differences among groups with pre-intervention values as covariates. Bonferroni corrections were applied to account for multiple comparisons. Results: Ten years after completing STRRIDE, there were a number of group-specific health and fitness legacy effects. Original participation in either the moderate intensity exercise or control group resulted in a 10.5% decrease in peak VO2 over the ensuing 10 years. Conversely, both vigorous intensity groups experienced only a 4.7% decrement in cardiorespiratory fitness over that time period. As compared to controls, all three exercise groups experienced smaller increases in waist circumference. Those who participated in moderate intensity exercise experienced the greatest 10-year reduction in fasting insulin. Compared to all other groups, the moderate intensity subjects had greater reductions in mean arterial pressure at the Reunion timepoint. Summary: Ten years after completing a randomized eight-month exercise training intervention, previously sedentary individuals exhibited group-specific differences consistent with an intervention-based legacy effect on cardiorespiratory fitness and cardiometabolic parameters. These findings highlight the critical need to better understand the sustained legacy health effects of exercise training interventions.
  • References (24)
  • Citations (2)
Published on Mar 9, 2017in Global Cardiology Science and Practice
Mohammed Amin Kashef1
Estimated H-index: 1
(Baystate Medical Center),
Gregory R. Giugliano7
Estimated H-index: 7
(Tufts University)
The West of Scotland Coronary Prevention Study (WOSCOPS) was a randomized, placebo- controlled, primary prevention trial of pravastatin in men aged 45 to 64 (mean age of 55 years) with no history of myocardial infarction at randomization. A total of 6,595 men, with a mean (SD) plasma cholesterol level of 272 (23) mg/dL and mean (SD) low density lipoprotein cholesterol (LDL-C) of 192 (17) mg/dL were randomly assigned to receive pravastatin 40 mg daily or placebo for five years. The primary outcom...
Published on Dec 1, 2016in Medicine and Science in Sports and Exercise4.48
Jessica L. Unick14
Estimated H-index: 14
(Brown University),
Sarah A. Gaussoin15
Estimated H-index: 15
(Wake Forest University)
+ 9 AuthorsDalane W. Kitzman76
Estimated H-index: 76
(Wake Forest University)
ABSTRACTPhysical activity (PA) has numerous health benefits, particularly for those with diabetes. However, rates of long-term PA participation are often poor.PurposeThis study examined the effect of an intensive lifestyle intervention (ILI) on objectively assessed PA for a 4-yr period among older a
Published on Oct 1, 2016in Diabetologia7.11
Cris A. Slentz35
Estimated H-index: 35
(Duke University),
Lori A. Bateman14
Estimated H-index: 14
(Duke University)
+ 8 AuthorsConnie W. Bales33
Estimated H-index: 33
(Duke University)
Aims/hypothesis Although the Diabetes Prevention Program (DPP) established lifestyle changes (diet, exercise and weight loss) as the ‘gold standard’ preventive therapy for diabetes, the relative contribution of exercise alone to the overall utility of the combined diet and exercise effect of DPP is unknown; furthermore, the optimal intensity of exercise for preventing progression to diabetes remains very controversial. To establish clinical efficacy, we undertook a study (2009 to 2013) to determ...
Published on Jun 1, 2014in The Lancet Diabetes & Endocrinology24.54
Guangwei Li10
Estimated H-index: 10
(China-Japan Friendship Hospital),
Ping Zhang37
Estimated H-index: 37
(CDC: Centers for Disease Control and Prevention)
+ 12 AuthorsJing Hong1
Estimated H-index: 1
(China-Japan Friendship Hospital)
Summary Background Lifestyle interventions among people with impaired glucose tolerance reduce the incidence of diabetes, but their effect on all-cause and cardiovascular disease mortality is unclear. We assessed the long-term effect of lifestyle intervention on long-term outcomes among adults with impaired glucose tolerance who participated in the Da Qing Diabetes Prevention Study. Methods The study was a cluster randomised trial in which 33 clinics in Da Qing, China—serving 577 adults with imp...
Published on Jul 1, 2013in Nephrology Dialysis Transplantation4.20
Rosanna Coppo37
Estimated H-index: 37
The term ‘legacy effect’—a memory of a treatment which produces benefits long after the cessation of the intervention—was adopted for the first time to describe the benefits of early and strict control of diabetes on cardiovascular complications. The search for a similar effect for early treatment of immune-mediated renal diseases, interrupting some self-amplification loops of the pathogenetical immunological mechanisms and leaving a permanent memory, is fascinating. Some recent reports suggest ...
Published on May 15, 2013in PLOS ONE2.78
Henrik Loe5
Estimated H-index: 5
(NTNU: Norwegian University of Science and Technology),
Øivind Rognmo19
Estimated H-index: 19
(NTNU: Norwegian University of Science and Technology)
+ 1 AuthorsUlrik Wisløff67
Estimated H-index: 67
(NTNU: Norwegian University of Science and Technology)
Purpose To provide a large reference material on aerobic fitness and exercise physiology data in a healthy population of Norwegian men and women aged 20–90 years. Methods Maximal and sub maximal levels of VO2, heart rate, oxygen pulse, and rating of perceived exertion (Borg scale: 6–20) were measured in 1929 men and 1881 women during treadmill running. Results The highest VO2max and maximal heart rate among men and women were observed in the youngest age group (20–29 years) and was 54.4±8.4 mL·k...
Published on Feb 1, 2013in Diabetologia7.11
Jaana Lindström64
Estimated H-index: 64
(National Institute for Health and Welfare),
Markku Peltonen56
Estimated H-index: 56
(National Institute for Health and Welfare)
+ 5 AuthorsJaakko Tuomilehto11
Estimated H-index: 11
(Danube University Krems)
Aims/hypothesis This study aimed to determine whether lifestyle intervention lasting for 4 years affected diabetes incidence, body weight, glycaemia or lifestyle over 13 years among individuals at high risk of type 2 diabetes.
Published on Oct 1, 2011in European Heart Journal23.24
Peter Sever64
Estimated H-index: 64
(Imperial College London),
Choon L. Chang11
Estimated H-index: 11
(Imperial College London)
+ 2 AuthorsNeil Poulter78
Estimated H-index: 78
(Imperial College London)
The aim of this study was to determine the outcome benefits in those originally assigned atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial—8 years after closure of the lipid-lowering arm (LLA) of the trial (ASCOT-LLA) among the UK population. Methods and results ASCOT-LLA was a factorially designed double-blind placebo-controlled trial of atorvastatin in 10 305 hypertensive patients enrolled into the ASCOT-Blood Pressure Lowering Arm (BPLA) of the trial and with total cholesterol con...
Published on Jan 1, 2010in Diabetes Care15.27
Myrlene A. Staten14
Estimated H-index: 14
(NIH: National Institutes of Health),
Michael P. Stern91
Estimated H-index: 91
(University of Texas Health Science Center at San Antonio)
+ 2 AuthorsScott E. Campbell3
Estimated H-index: 3
(American Diabetes Association)
Diabetes, primarily type 2 diabetes, has increased in prevalence throughout the world and current projections suggest a continued rise worldwide for at least the next quarter century. Insulin resistance, which frequently accompanies obesity, is known to be a key factor in the pathogenic development of type 2 diabetes (1–6). Type 2 diabetes occurs when insulin secretion is no longer sufficient to compensate for the resistance to the actions of insulin. Measurements of insulin sensitivity and secr...
Published on Nov 14, 2009in The Lancet59.10
Ronald N. Goldberg46
Estimated H-index: 46
Elizabeth M. Venditti18
Estimated H-index: 18
+ 8 AuthorsA T Brenneman1
Estimated H-index: 1
Cited By2
Published on Jun 13, 2019in Nature Reviews Endocrinology24.65
Samuel Dagogo-Jack36
Estimated H-index: 36
(UTHSC: University of Tennessee Health Science Center)
Lifestyle interventions in patients with prediabetes can delay the onset of type 2 diabetes mellitus, but long-term data on diabetes complications are lacking. A new report from the Da Qing Study provides data on the effect of lifestyle interventions on diabetes mellitus complications and mortality in patients with prediabetes who were followed up for 30 years.
Published on May 9, 2019in bioRxiv
Ricardo Laranjeiro2
Estimated H-index: 2
(RU: Rutgers University),
Girish Harinath3
Estimated H-index: 3
(RU: Rutgers University)
+ 5 AuthorsMonica Driscoll41
Estimated H-index: 41
(RU: Rutgers University)
Exercise can protect against cardiovascular disease, neurodegenerative disease, diabetes, cancer, and age-associated declines in muscle, immune, and cognitive function. In fact, regular physical exercise is the most powerful intervention known to enhance robustness of health and aging. Still, the molecular and cellular mechanisms that mediate system-wide exercise benefits remain poorly understood, especially as applies to "off target" tissues that do not participate directly in training activity...
View next paperAbstract 46: Legacy Effects of STRRIDE Exercise Training Programs on Cardiometabolic Health Observed Ten Years Later